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SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
Human Silent Information Regulator Type 1 (SIRT1) is an NAD(+)-dependent deacetylase protein which is an intermediary of cellular metabolism in gene silencing and aging. SIRT1 has been extensively investigated and shown to delay senescence; however, less is known about the regulation of SIRT1 during...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995042/ https://www.ncbi.nlm.nih.gov/pubmed/20660480 http://dx.doi.org/10.1093/nar/gkq609 |