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Error correction of next-generation sequencing data and reliable estimation of HIV quasispecies

Next-generation sequencing technologies can be used to analyse genetically heterogeneous samples at unprecedented detail. The high coverage achievable with these methods enables the detection of many low-frequency variants. However, sequencing errors complicate the analysis of mixed populations and...

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Detalles Bibliográficos
Autores principales:	Zagordi, Osvaldo, Klein, Rolf, Däumer, Martin, Beerenwinkel, Niko
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995073/ https://www.ncbi.nlm.nih.gov/pubmed/20671025 http://dx.doi.org/10.1093/nar/gkq655

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