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Deconstructing nucleotide binding activity of the Mdm2 RING domain

Mdm2, a central negative regulator of the p53 tumor suppressor, possesses a Really Interesting New Gene (RING) domain within its C-terminus. In addition to E3 ubiquitin ligase activity, the Mdm2 RING preferentially binds adenine base nucleotides, and such binding leads to a conformational change in...

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Detalles Bibliográficos
Autores principales:	Priest, Christina, Prives, Carol, Poyurovsky, Masha V.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995081/ https://www.ncbi.nlm.nih.gov/pubmed/20671028 http://dx.doi.org/10.1093/nar/gkq669

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