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Chemical discrimination between dC and (5Me)dC via their hydroxylamine adducts
The presence of the methylated nucleobase (5Me)dC in CpG islands is a key factor that determines gene silencing. False methylation patterns are responsible for deteriorated cellular development and are a hallmark of many cancers. Today genes can be sequenced for the content of (5Me)dC only with the...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995083/ https://www.ncbi.nlm.nih.gov/pubmed/20813757 http://dx.doi.org/10.1093/nar/gkq724 |