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Protein kinase A–induced myofilament desensitization to Ca(2+) as a result of phosphorylation of cardiac myosin–binding protein C

In skinned myocardium, cyclic AMP–dependent protein kinase A (PKA)-catalyzed phosphorylation of cardiac myosin–binding protein C (cMyBP-C) and cardiac troponin I (cTnI) is associated with a reduction in the Ca(2+) responsiveness of myofilaments and an acceleration in the kinetics of cross-bridge cyc...

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Detalles Bibliográficos
Autores principales:	Chen, Peter P., Patel, Jitandrakumar R., Rybakova, Inna N., Walker, Jeffery W., Moss, Richard L.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995154/ https://www.ncbi.nlm.nih.gov/pubmed/21115695 http://dx.doi.org/10.1085/jgp.201010448

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