Cell fate transitions and the replication timing decision point

Recent findings suggest that large-scale remodeling of three dimensional (3D) chromatin architecture occurs during a brief period in early G1 phase termed the replication timing decision point (TDP). In this speculative article, I suggest that the TDP may represent an as yet unappreciated window of...

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Detalles Bibliográficos
Autor principal: Gilbert, David M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995162/
https://www.ncbi.nlm.nih.gov/pubmed/21115801
http://dx.doi.org/10.1083/jcb.201007125
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author Gilbert, David M.
author_facet Gilbert, David M.
author_sort Gilbert, David M.
collection PubMed
description Recent findings suggest that large-scale remodeling of three dimensional (3D) chromatin architecture occurs during a brief period in early G1 phase termed the replication timing decision point (TDP). In this speculative article, I suggest that the TDP may represent an as yet unappreciated window of opportunity for extracellular cues to influence 3D architecture during stem cell fate decisions. I also describe several testable predictions of this hypothesis.
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spelling pubmed-29951622011-05-29 Cell fate transitions and the replication timing decision point Gilbert, David M. J Cell Biol Reviews Recent findings suggest that large-scale remodeling of three dimensional (3D) chromatin architecture occurs during a brief period in early G1 phase termed the replication timing decision point (TDP). In this speculative article, I suggest that the TDP may represent an as yet unappreciated window of opportunity for extracellular cues to influence 3D architecture during stem cell fate decisions. I also describe several testable predictions of this hypothesis. The Rockefeller University Press 2010-11-29 /pmc/articles/PMC2995162/ /pubmed/21115801 http://dx.doi.org/10.1083/jcb.201007125 Text en © 2010 Gilbert This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Gilbert, David M.
Cell fate transitions and the replication timing decision point
title Cell fate transitions and the replication timing decision point
title_full Cell fate transitions and the replication timing decision point
title_fullStr Cell fate transitions and the replication timing decision point
title_full_unstemmed Cell fate transitions and the replication timing decision point
title_short Cell fate transitions and the replication timing decision point
title_sort cell fate transitions and the replication timing decision point
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995162/
https://www.ncbi.nlm.nih.gov/pubmed/21115801
http://dx.doi.org/10.1083/jcb.201007125
work_keys_str_mv AT gilbertdavidm cellfatetransitionsandthereplicationtimingdecisionpoint

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