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Effect of Probiotic Lactobacillus (Lacidofil® Cap) for the Prevention of Antibiotic-associated Diarrhea: A Prospective, Randomized, Double-blind, Multicenter Study
Antibiotic-associated diarrhea (AAD) is a common complication of antibiotic use. There is growing interest in probiotics for the treatment of AAD and Clostridium difficile infection because of the wide availability of probiotics. The aim of this multicenter, randomized, placebo-controlled, double-bl...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Academy of Medical Sciences
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995234/ https://www.ncbi.nlm.nih.gov/pubmed/21165295 http://dx.doi.org/10.3346/jkms.2010.25.12.1784 |
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author | Song, Hyun Joo Kim, Jin-Yong Jung, Sung-Ae Kim, Seong-Eun Park, Hye-Sook Jeong, Yoolwon Hong, Sung Pil Cheon, Jae Hee Kim, Won Ho Kim, Hyo-Jong Ye, Byong Duk Yang, Suk-Kyun Kim, Sang-Woo Shin, Sung-Jae Kim, Hyun-Soo Sung, Jae-Kyu Kim, Eun Young |
author_facet | Song, Hyun Joo Kim, Jin-Yong Jung, Sung-Ae Kim, Seong-Eun Park, Hye-Sook Jeong, Yoolwon Hong, Sung Pil Cheon, Jae Hee Kim, Won Ho Kim, Hyo-Jong Ye, Byong Duk Yang, Suk-Kyun Kim, Sang-Woo Shin, Sung-Jae Kim, Hyun-Soo Sung, Jae-Kyu Kim, Eun Young |
author_sort | Song, Hyun Joo |
collection | PubMed |
description | Antibiotic-associated diarrhea (AAD) is a common complication of antibiotic use. There is growing interest in probiotics for the treatment of AAD and Clostridium difficile infection because of the wide availability of probiotics. The aim of this multicenter, randomized, placebo-controlled, double-blind trial was to assess the efficacy of probiotic Lactobacillus (Lacidofil® cap) for the prevention of AAD in adults. From September 2008 to November 2009, a total of 214 patients with respiratory tract infection who had begun receiving antibiotics were randomized to receive Lactobacillus (Lacidofil® cap) or placebo for 14 days. Patients recorded bowel frequency and stool consistency daily for 14 days. The primary outcome was the proportion of patients who developed AAD within 14 days of enrollment. AAD developed in 4 (3.9%) of 103 patients in the Lactobacillus group and in 8 (7.2%) of 111 patients in the placebo group (P=0.44). However, the Lactobacillus group showed lower change in bowel frequency and consistency (50/103, 48.5%) than the placebo group (35/111, 31.5%) (P=0.01). Although the Lacidofil® cap does not reduce the rate of occurrence of AAD in adult patients with respiratory tract infection who have taken antibiotics, the Lactobacillus group maintains their bowel habits to a greater extent than the placebo group. |
format | Text |
id | pubmed-2995234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-29952342010-12-16 Effect of Probiotic Lactobacillus (Lacidofil® Cap) for the Prevention of Antibiotic-associated Diarrhea: A Prospective, Randomized, Double-blind, Multicenter Study Song, Hyun Joo Kim, Jin-Yong Jung, Sung-Ae Kim, Seong-Eun Park, Hye-Sook Jeong, Yoolwon Hong, Sung Pil Cheon, Jae Hee Kim, Won Ho Kim, Hyo-Jong Ye, Byong Duk Yang, Suk-Kyun Kim, Sang-Woo Shin, Sung-Jae Kim, Hyun-Soo Sung, Jae-Kyu Kim, Eun Young J Korean Med Sci Original Article Antibiotic-associated diarrhea (AAD) is a common complication of antibiotic use. There is growing interest in probiotics for the treatment of AAD and Clostridium difficile infection because of the wide availability of probiotics. The aim of this multicenter, randomized, placebo-controlled, double-blind trial was to assess the efficacy of probiotic Lactobacillus (Lacidofil® cap) for the prevention of AAD in adults. From September 2008 to November 2009, a total of 214 patients with respiratory tract infection who had begun receiving antibiotics were randomized to receive Lactobacillus (Lacidofil® cap) or placebo for 14 days. Patients recorded bowel frequency and stool consistency daily for 14 days. The primary outcome was the proportion of patients who developed AAD within 14 days of enrollment. AAD developed in 4 (3.9%) of 103 patients in the Lactobacillus group and in 8 (7.2%) of 111 patients in the placebo group (P=0.44). However, the Lactobacillus group showed lower change in bowel frequency and consistency (50/103, 48.5%) than the placebo group (35/111, 31.5%) (P=0.01). Although the Lacidofil® cap does not reduce the rate of occurrence of AAD in adult patients with respiratory tract infection who have taken antibiotics, the Lactobacillus group maintains their bowel habits to a greater extent than the placebo group. The Korean Academy of Medical Sciences 2010-12 2010-11-24 /pmc/articles/PMC2995234/ /pubmed/21165295 http://dx.doi.org/10.3346/jkms.2010.25.12.1784 Text en © 2010 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Song, Hyun Joo Kim, Jin-Yong Jung, Sung-Ae Kim, Seong-Eun Park, Hye-Sook Jeong, Yoolwon Hong, Sung Pil Cheon, Jae Hee Kim, Won Ho Kim, Hyo-Jong Ye, Byong Duk Yang, Suk-Kyun Kim, Sang-Woo Shin, Sung-Jae Kim, Hyun-Soo Sung, Jae-Kyu Kim, Eun Young Effect of Probiotic Lactobacillus (Lacidofil® Cap) for the Prevention of Antibiotic-associated Diarrhea: A Prospective, Randomized, Double-blind, Multicenter Study |
title | Effect of Probiotic Lactobacillus (Lacidofil® Cap) for the Prevention of Antibiotic-associated Diarrhea: A Prospective, Randomized, Double-blind, Multicenter Study |
title_full | Effect of Probiotic Lactobacillus (Lacidofil® Cap) for the Prevention of Antibiotic-associated Diarrhea: A Prospective, Randomized, Double-blind, Multicenter Study |
title_fullStr | Effect of Probiotic Lactobacillus (Lacidofil® Cap) for the Prevention of Antibiotic-associated Diarrhea: A Prospective, Randomized, Double-blind, Multicenter Study |
title_full_unstemmed | Effect of Probiotic Lactobacillus (Lacidofil® Cap) for the Prevention of Antibiotic-associated Diarrhea: A Prospective, Randomized, Double-blind, Multicenter Study |
title_short | Effect of Probiotic Lactobacillus (Lacidofil® Cap) for the Prevention of Antibiotic-associated Diarrhea: A Prospective, Randomized, Double-blind, Multicenter Study |
title_sort | effect of probiotic lactobacillus (lacidofil® cap) for the prevention of antibiotic-associated diarrhea: a prospective, randomized, double-blind, multicenter study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995234/ https://www.ncbi.nlm.nih.gov/pubmed/21165295 http://dx.doi.org/10.3346/jkms.2010.25.12.1784 |
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