Cargando…

Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia

Although gynecomastia is a well-defined paraneoplastic syndrome in patients with non-small cell lung cancer, the association with pleomorphic carcinoma has not been reported. A 50-yr-old man presented with bilateral gynecomastia and elevated serum beta-human chorionic gonadotropin (βhCG) level. Ches...

Descripción completa

Detalles Bibliográficos
Autores principales: Okutur, Kerem, Hasbal, Baris, Aydin, Kubra, Bozkurt, Mustafa, Namal, Esat, Oz, Buge, Kaynak, Kamil, Demir, Gokhan
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995238/
https://www.ncbi.nlm.nih.gov/pubmed/21165299
http://dx.doi.org/10.3346/jkms.2010.25.12.1805
_version_ 1782193071658631168
author Okutur, Kerem
Hasbal, Baris
Aydin, Kubra
Bozkurt, Mustafa
Namal, Esat
Oz, Buge
Kaynak, Kamil
Demir, Gokhan
author_facet Okutur, Kerem
Hasbal, Baris
Aydin, Kubra
Bozkurt, Mustafa
Namal, Esat
Oz, Buge
Kaynak, Kamil
Demir, Gokhan
author_sort Okutur, Kerem
collection PubMed
description Although gynecomastia is a well-defined paraneoplastic syndrome in patients with non-small cell lung cancer, the association with pleomorphic carcinoma has not been reported. A 50-yr-old man presented with bilateral gynecomastia and elevated serum beta-human chorionic gonadotropin (βhCG) level. Chest tomography showed a mass in the right middle lobe. Right middle lobectomy and mediastinal lymph node dissection were performed. βhCG levels decreased rapidly after surgery. Histological examination revealed pleomorphic carcinoma with positive immunostaining for βhCG. Serum βhCG levels began to increase gradually on postoperatively 4th month. Computed tomography detected recurrence and chemotherapy was started. After second cycle of chemotherapy, βhCG levels decreased dramatically again and tomography showed regression in mass. Patient died 6 months later due to brain metastasis. βhCG expression may be associated with aggressive clinical course and increased risk of recurrence, also βhCG levels may be used to evaluate therapy response in patients with pleomorphic carcinoma.
format Text
id pubmed-2995238
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-29952382010-12-16 Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia Okutur, Kerem Hasbal, Baris Aydin, Kubra Bozkurt, Mustafa Namal, Esat Oz, Buge Kaynak, Kamil Demir, Gokhan J Korean Med Sci Case Report Although gynecomastia is a well-defined paraneoplastic syndrome in patients with non-small cell lung cancer, the association with pleomorphic carcinoma has not been reported. A 50-yr-old man presented with bilateral gynecomastia and elevated serum beta-human chorionic gonadotropin (βhCG) level. Chest tomography showed a mass in the right middle lobe. Right middle lobectomy and mediastinal lymph node dissection were performed. βhCG levels decreased rapidly after surgery. Histological examination revealed pleomorphic carcinoma with positive immunostaining for βhCG. Serum βhCG levels began to increase gradually on postoperatively 4th month. Computed tomography detected recurrence and chemotherapy was started. After second cycle of chemotherapy, βhCG levels decreased dramatically again and tomography showed regression in mass. Patient died 6 months later due to brain metastasis. βhCG expression may be associated with aggressive clinical course and increased risk of recurrence, also βhCG levels may be used to evaluate therapy response in patients with pleomorphic carcinoma. The Korean Academy of Medical Sciences 2010-12 2010-11-24 /pmc/articles/PMC2995238/ /pubmed/21165299 http://dx.doi.org/10.3346/jkms.2010.25.12.1805 Text en © 2010 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Okutur, Kerem
Hasbal, Baris
Aydin, Kubra
Bozkurt, Mustafa
Namal, Esat
Oz, Buge
Kaynak, Kamil
Demir, Gokhan
Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia
title Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia
title_full Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia
title_fullStr Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia
title_full_unstemmed Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia
title_short Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia
title_sort pleomorphic carcinoma of the lung with high serum beta-human chorionic gonadotropin level and gynecomastia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995238/
https://www.ncbi.nlm.nih.gov/pubmed/21165299
http://dx.doi.org/10.3346/jkms.2010.25.12.1805
work_keys_str_mv AT okuturkerem pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia
AT hasbalbaris pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia
AT aydinkubra pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia
AT bozkurtmustafa pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia
AT namalesat pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia
AT ozbuge pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia
AT kaynakkamil pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia
AT demirgokhan pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia