Cargando…
Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia
Although gynecomastia is a well-defined paraneoplastic syndrome in patients with non-small cell lung cancer, the association with pleomorphic carcinoma has not been reported. A 50-yr-old man presented with bilateral gynecomastia and elevated serum beta-human chorionic gonadotropin (βhCG) level. Ches...
Autores principales: | , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995238/ https://www.ncbi.nlm.nih.gov/pubmed/21165299 http://dx.doi.org/10.3346/jkms.2010.25.12.1805 |
_version_ | 1782193071658631168 |
---|---|
author | Okutur, Kerem Hasbal, Baris Aydin, Kubra Bozkurt, Mustafa Namal, Esat Oz, Buge Kaynak, Kamil Demir, Gokhan |
author_facet | Okutur, Kerem Hasbal, Baris Aydin, Kubra Bozkurt, Mustafa Namal, Esat Oz, Buge Kaynak, Kamil Demir, Gokhan |
author_sort | Okutur, Kerem |
collection | PubMed |
description | Although gynecomastia is a well-defined paraneoplastic syndrome in patients with non-small cell lung cancer, the association with pleomorphic carcinoma has not been reported. A 50-yr-old man presented with bilateral gynecomastia and elevated serum beta-human chorionic gonadotropin (βhCG) level. Chest tomography showed a mass in the right middle lobe. Right middle lobectomy and mediastinal lymph node dissection were performed. βhCG levels decreased rapidly after surgery. Histological examination revealed pleomorphic carcinoma with positive immunostaining for βhCG. Serum βhCG levels began to increase gradually on postoperatively 4th month. Computed tomography detected recurrence and chemotherapy was started. After second cycle of chemotherapy, βhCG levels decreased dramatically again and tomography showed regression in mass. Patient died 6 months later due to brain metastasis. βhCG expression may be associated with aggressive clinical course and increased risk of recurrence, also βhCG levels may be used to evaluate therapy response in patients with pleomorphic carcinoma. |
format | Text |
id | pubmed-2995238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-29952382010-12-16 Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia Okutur, Kerem Hasbal, Baris Aydin, Kubra Bozkurt, Mustafa Namal, Esat Oz, Buge Kaynak, Kamil Demir, Gokhan J Korean Med Sci Case Report Although gynecomastia is a well-defined paraneoplastic syndrome in patients with non-small cell lung cancer, the association with pleomorphic carcinoma has not been reported. A 50-yr-old man presented with bilateral gynecomastia and elevated serum beta-human chorionic gonadotropin (βhCG) level. Chest tomography showed a mass in the right middle lobe. Right middle lobectomy and mediastinal lymph node dissection were performed. βhCG levels decreased rapidly after surgery. Histological examination revealed pleomorphic carcinoma with positive immunostaining for βhCG. Serum βhCG levels began to increase gradually on postoperatively 4th month. Computed tomography detected recurrence and chemotherapy was started. After second cycle of chemotherapy, βhCG levels decreased dramatically again and tomography showed regression in mass. Patient died 6 months later due to brain metastasis. βhCG expression may be associated with aggressive clinical course and increased risk of recurrence, also βhCG levels may be used to evaluate therapy response in patients with pleomorphic carcinoma. The Korean Academy of Medical Sciences 2010-12 2010-11-24 /pmc/articles/PMC2995238/ /pubmed/21165299 http://dx.doi.org/10.3346/jkms.2010.25.12.1805 Text en © 2010 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Okutur, Kerem Hasbal, Baris Aydin, Kubra Bozkurt, Mustafa Namal, Esat Oz, Buge Kaynak, Kamil Demir, Gokhan Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia |
title | Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia |
title_full | Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia |
title_fullStr | Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia |
title_full_unstemmed | Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia |
title_short | Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia |
title_sort | pleomorphic carcinoma of the lung with high serum beta-human chorionic gonadotropin level and gynecomastia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995238/ https://www.ncbi.nlm.nih.gov/pubmed/21165299 http://dx.doi.org/10.3346/jkms.2010.25.12.1805 |
work_keys_str_mv | AT okuturkerem pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia AT hasbalbaris pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia AT aydinkubra pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia AT bozkurtmustafa pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia AT namalesat pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia AT ozbuge pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia AT kaynakkamil pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia AT demirgokhan pleomorphiccarcinomaofthelungwithhighserumbetahumanchorionicgonadotropinlevelandgynecomastia |