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Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats
OBJECTIVE: To investigate the effect of the methanolic extract of Erythrina variegata (Linn.) var Orientalis (Fabaceae) seeds (MEEV) in reducing the cholesterol levels and as well as antioxidant in experimentally induced hyperlipidemic rats. MATERIALS AND METHODS: Doses of 200 and 400 mg/kg of the e...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996074/ https://www.ncbi.nlm.nih.gov/pubmed/21180471 http://dx.doi.org/10.4103/0975-7406.72139 |
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author | Balamurugan, G. Shantha, A. |
author_facet | Balamurugan, G. Shantha, A. |
author_sort | Balamurugan, G. |
collection | PubMed |
description | OBJECTIVE: To investigate the effect of the methanolic extract of Erythrina variegata (Linn.) var Orientalis (Fabaceae) seeds (MEEV) in reducing the cholesterol levels and as well as antioxidant in experimentally induced hyperlipidemic rats. MATERIALS AND METHODS: Doses of 200 and 400 mg/kg of the extract were evaluated for its effect on lipid profile, HMG-CoA reductase, and on antioxidant enzymes in high-fat diet (HFD) induced hyperlipidemia. RESULTS AND CONCLUSION: The elevated levels of total cholesterol, triglycerides, low-density lipoprotein, and very low density lipoprotein due to HFD was reduced by concurrent treatment with MEEV (200 and 400 mg/kg) significantly (P<0.001). A significant reduction (P<0.001) in high-density lipoprotein was noticed in HFD fed groups; however, a nonsignificant increment was produced by the administration of MEEV (200 and 400 mg/kg). The HMG-CoA reductase activity was increased in HFD fed animals significantly (P<0.001) and was reduced by MEEV 400 mg/kg significantly (P<0.001). There was a noticed increase in the body weight and mesenteric fat pad weight in HFD fed group (P<0.001), which was reduced by the administration of MEEV (200 and 400 mg/kg). The antioxidant enzymes such as superoxide dismutase and catalase were reduced significantly in the HFD fed group, whose levels were increased significantly (P<0.001) by the administration of MEEV (200 and 400 mg/kg). Lipid peroxidation was increased in HFD fed animals, which was reduced significantly (P<0.001) by the treatment with MEEV (200 and 400 mg/kg). |
format | Text |
id | pubmed-2996074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-29960742010-12-21 Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats Balamurugan, G. Shantha, A. J Pharm Bioallied Sci Original Article OBJECTIVE: To investigate the effect of the methanolic extract of Erythrina variegata (Linn.) var Orientalis (Fabaceae) seeds (MEEV) in reducing the cholesterol levels and as well as antioxidant in experimentally induced hyperlipidemic rats. MATERIALS AND METHODS: Doses of 200 and 400 mg/kg of the extract were evaluated for its effect on lipid profile, HMG-CoA reductase, and on antioxidant enzymes in high-fat diet (HFD) induced hyperlipidemia. RESULTS AND CONCLUSION: The elevated levels of total cholesterol, triglycerides, low-density lipoprotein, and very low density lipoprotein due to HFD was reduced by concurrent treatment with MEEV (200 and 400 mg/kg) significantly (P<0.001). A significant reduction (P<0.001) in high-density lipoprotein was noticed in HFD fed groups; however, a nonsignificant increment was produced by the administration of MEEV (200 and 400 mg/kg). The HMG-CoA reductase activity was increased in HFD fed animals significantly (P<0.001) and was reduced by MEEV 400 mg/kg significantly (P<0.001). There was a noticed increase in the body weight and mesenteric fat pad weight in HFD fed group (P<0.001), which was reduced by the administration of MEEV (200 and 400 mg/kg). The antioxidant enzymes such as superoxide dismutase and catalase were reduced significantly in the HFD fed group, whose levels were increased significantly (P<0.001) by the administration of MEEV (200 and 400 mg/kg). Lipid peroxidation was increased in HFD fed animals, which was reduced significantly (P<0.001) by the treatment with MEEV (200 and 400 mg/kg). Medknow Publications 2010 /pmc/articles/PMC2996074/ /pubmed/21180471 http://dx.doi.org/10.4103/0975-7406.72139 Text en © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Balamurugan, G. Shantha, A. Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats |
title | Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats |
title_full | Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats |
title_fullStr | Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats |
title_full_unstemmed | Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats |
title_short | Effect of Erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats |
title_sort | effect of erythrina variegata seed extract on hyperlipidemia elicited by high-fat diet in wistar rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996074/ https://www.ncbi.nlm.nih.gov/pubmed/21180471 http://dx.doi.org/10.4103/0975-7406.72139 |
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