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Transplanted Oligodendrocytes and Motoneuron Progenitors Generated from Human Embryonic Stem Cells Promote Locomotor Recovery After Spinal Cord Transection

Human embryonic stem cells (hESC) hold great promise for the treatment of patients with many neurodegenerative diseases particularly those arising from cell loss or neural dysfunction including spinal cord injury. This study evaluates the therapeutic effects of transplanted hESC-derived oligodendroc...

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Autores principales: Erceg, Slaven, Ronaghi, Mohammad, Oria, Marc, García Roselló, Mireia, Aragó, Maria Amparo Pérez, Lopez, Maria Gomez, Radojevic, Ivana, Moreno-Manzano, Victoria, Rodríguez-Jiménez, Francisco-Javier, Shanker Bhattacharya, Shom, Cordoba, Juan, Stojkovic, Miodrag
Formato: Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996083/
https://www.ncbi.nlm.nih.gov/pubmed/20665739
http://dx.doi.org/10.1002/stem.489
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author Erceg, Slaven
Ronaghi, Mohammad
Oria, Marc
García Roselló, Mireia
Aragó, Maria Amparo Pérez
Lopez, Maria Gomez
Radojevic, Ivana
Moreno-Manzano, Victoria
Rodríguez-Jiménez, Francisco-Javier
Shanker Bhattacharya, Shom
Cordoba, Juan
Stojkovic, Miodrag
author_facet Erceg, Slaven
Ronaghi, Mohammad
Oria, Marc
García Roselló, Mireia
Aragó, Maria Amparo Pérez
Lopez, Maria Gomez
Radojevic, Ivana
Moreno-Manzano, Victoria
Rodríguez-Jiménez, Francisco-Javier
Shanker Bhattacharya, Shom
Cordoba, Juan
Stojkovic, Miodrag
author_sort Erceg, Slaven
collection PubMed
description Human embryonic stem cells (hESC) hold great promise for the treatment of patients with many neurodegenerative diseases particularly those arising from cell loss or neural dysfunction including spinal cord injury. This study evaluates the therapeutic effects of transplanted hESC-derived oligodendrocyte progenitors (OPC) and/or motoneuron progenitors (MP) on axonal remyelination and functional recovery of adult rats after complete spinal cord transection. OPC and/or MP were grafted into the site of injury in the acute phase. Based on Basso-Beattie-Bresnahan scores recovery of locomotor function was significantly enhanced in rats treated with OPC and/or MP when compared with control animals. When transplanted into the spinal cord immediately after complete transection, OPC and MP survived, migrated, and differentiated into mature oligodendrocytes and neurons showing in vivo electrophysiological activity. Taken together, these results indicate that OPC and MP derived from hESC could be a useful therapeutic strategy to repair injured spinal cord. Stem Cells 2010; 28:1541–1549.
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spelling pubmed-29960832010-12-28 Transplanted Oligodendrocytes and Motoneuron Progenitors Generated from Human Embryonic Stem Cells Promote Locomotor Recovery After Spinal Cord Transection Erceg, Slaven Ronaghi, Mohammad Oria, Marc García Roselló, Mireia Aragó, Maria Amparo Pérez Lopez, Maria Gomez Radojevic, Ivana Moreno-Manzano, Victoria Rodríguez-Jiménez, Francisco-Javier Shanker Bhattacharya, Shom Cordoba, Juan Stojkovic, Miodrag Stem Cells Embryonic Stem Cells/Induced Pluripotent Stem Cells Human embryonic stem cells (hESC) hold great promise for the treatment of patients with many neurodegenerative diseases particularly those arising from cell loss or neural dysfunction including spinal cord injury. This study evaluates the therapeutic effects of transplanted hESC-derived oligodendrocyte progenitors (OPC) and/or motoneuron progenitors (MP) on axonal remyelination and functional recovery of adult rats after complete spinal cord transection. OPC and/or MP were grafted into the site of injury in the acute phase. Based on Basso-Beattie-Bresnahan scores recovery of locomotor function was significantly enhanced in rats treated with OPC and/or MP when compared with control animals. When transplanted into the spinal cord immediately after complete transection, OPC and MP survived, migrated, and differentiated into mature oligodendrocytes and neurons showing in vivo electrophysiological activity. Taken together, these results indicate that OPC and MP derived from hESC could be a useful therapeutic strategy to repair injured spinal cord. Stem Cells 2010; 28:1541–1549. Wiley Subscription Services, Inc., A Wiley Company 2010-09 2010-07-27 /pmc/articles/PMC2996083/ /pubmed/20665739 http://dx.doi.org/10.1002/stem.489 Text en Copyright © 2010 AlphaMed Press http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Embryonic Stem Cells/Induced Pluripotent Stem Cells
Erceg, Slaven
Ronaghi, Mohammad
Oria, Marc
García Roselló, Mireia
Aragó, Maria Amparo Pérez
Lopez, Maria Gomez
Radojevic, Ivana
Moreno-Manzano, Victoria
Rodríguez-Jiménez, Francisco-Javier
Shanker Bhattacharya, Shom
Cordoba, Juan
Stojkovic, Miodrag
Transplanted Oligodendrocytes and Motoneuron Progenitors Generated from Human Embryonic Stem Cells Promote Locomotor Recovery After Spinal Cord Transection
title Transplanted Oligodendrocytes and Motoneuron Progenitors Generated from Human Embryonic Stem Cells Promote Locomotor Recovery After Spinal Cord Transection
title_full Transplanted Oligodendrocytes and Motoneuron Progenitors Generated from Human Embryonic Stem Cells Promote Locomotor Recovery After Spinal Cord Transection
title_fullStr Transplanted Oligodendrocytes and Motoneuron Progenitors Generated from Human Embryonic Stem Cells Promote Locomotor Recovery After Spinal Cord Transection
title_full_unstemmed Transplanted Oligodendrocytes and Motoneuron Progenitors Generated from Human Embryonic Stem Cells Promote Locomotor Recovery After Spinal Cord Transection
title_short Transplanted Oligodendrocytes and Motoneuron Progenitors Generated from Human Embryonic Stem Cells Promote Locomotor Recovery After Spinal Cord Transection
title_sort transplanted oligodendrocytes and motoneuron progenitors generated from human embryonic stem cells promote locomotor recovery after spinal cord transection
topic Embryonic Stem Cells/Induced Pluripotent Stem Cells
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996083/
https://www.ncbi.nlm.nih.gov/pubmed/20665739
http://dx.doi.org/10.1002/stem.489
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