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Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum

The new secondary metabolites verrucosidinol (1) and its derivative verrucosidinol acetate (2), together with a potent neurotoxin verrucosidin (3), a congener norverrucosidin (4) and a mixture of two known phytotoxic metabolites terrestric acids (5 and 6), were isolated from the marine derived fungu...

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Autores principales: Yu, Ke, Ren, Biao, Wei, Junli, Chen, Caixia, Sun, Jinsheng, Song, Fuhang, Dai, Huanqin, Zhang, Lixin
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996174/
https://www.ncbi.nlm.nih.gov/pubmed/21139842
http://dx.doi.org/10.3390/md8112744
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author Yu, Ke
Ren, Biao
Wei, Junli
Chen, Caixia
Sun, Jinsheng
Song, Fuhang
Dai, Huanqin
Zhang, Lixin
author_facet Yu, Ke
Ren, Biao
Wei, Junli
Chen, Caixia
Sun, Jinsheng
Song, Fuhang
Dai, Huanqin
Zhang, Lixin
author_sort Yu, Ke
collection PubMed
description The new secondary metabolites verrucosidinol (1) and its derivative verrucosidinol acetate (2), together with a potent neurotoxin verrucosidin (3), a congener norverrucosidin (4) and a mixture of two known phytotoxic metabolites terrestric acids (5 and 6), were isolated from the marine derived fungus Penicillium aurantiogriseum. Verrucosidinol has a ring-opened ethylene oxide moiety in the polyene α-pyrone skeleton, and verrucosidinol acetate is its acetate derivative. The chemical structures were determined by comparing with literature data and a combination of spectroscopic techniques, including high resolution mass spectrum and two-dimentional nuclear magnetic resonance spectroscopic analysis.
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spelling pubmed-29961742010-12-06 Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum Yu, Ke Ren, Biao Wei, Junli Chen, Caixia Sun, Jinsheng Song, Fuhang Dai, Huanqin Zhang, Lixin Mar Drugs Article The new secondary metabolites verrucosidinol (1) and its derivative verrucosidinol acetate (2), together with a potent neurotoxin verrucosidin (3), a congener norverrucosidin (4) and a mixture of two known phytotoxic metabolites terrestric acids (5 and 6), were isolated from the marine derived fungus Penicillium aurantiogriseum. Verrucosidinol has a ring-opened ethylene oxide moiety in the polyene α-pyrone skeleton, and verrucosidinol acetate is its acetate derivative. The chemical structures were determined by comparing with literature data and a combination of spectroscopic techniques, including high resolution mass spectrum and two-dimentional nuclear magnetic resonance spectroscopic analysis. Molecular Diversity Preservation International 2010-11-01 /pmc/articles/PMC2996174/ /pubmed/21139842 http://dx.doi.org/10.3390/md8112744 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yu, Ke
Ren, Biao
Wei, Junli
Chen, Caixia
Sun, Jinsheng
Song, Fuhang
Dai, Huanqin
Zhang, Lixin
Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum
title Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum
title_full Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum
title_fullStr Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum
title_full_unstemmed Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum
title_short Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum
title_sort verrucisidinol and verrucosidinol acetate, two pyrone-type polyketides isolated from a marine derived fungus, penicillium aurantiogriseum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996174/
https://www.ncbi.nlm.nih.gov/pubmed/21139842
http://dx.doi.org/10.3390/md8112744
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