Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum

Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O–S (1–5) and a new “monomeric” cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC,...

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Autores principales: Yan, Pengcheng, Deng, Zhiwei, van Ofwegen, Leen, Proksch, Peter, Lin, Wenhan
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996179/
https://www.ncbi.nlm.nih.gov/pubmed/21139847
http://dx.doi.org/10.3390/md8112848
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author Yan, Pengcheng
Deng, Zhiwei
van Ofwegen, Leen
Proksch, Peter
Lin, Wenhan
author_facet Yan, Pengcheng
Deng, Zhiwei
van Ofwegen, Leen
Proksch, Peter
Lin, Wenhan
author_sort Yan, Pengcheng
collection PubMed
description Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O–S (1–5) and a new “monomeric” cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic data in association with MS and IR data. Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophages, while lobophytones Q and T showed inhibitory activities against the bacteria S. aureus and S. pneumoniae.
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spelling pubmed-29961792010-12-06 Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum Yan, Pengcheng Deng, Zhiwei van Ofwegen, Leen Proksch, Peter Lin, Wenhan Mar Drugs Article Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O–S (1–5) and a new “monomeric” cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic data in association with MS and IR data. Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophages, while lobophytones Q and T showed inhibitory activities against the bacteria S. aureus and S. pneumoniae. Molecular Diversity Preservation International 2010-11-10 /pmc/articles/PMC2996179/ /pubmed/21139847 http://dx.doi.org/10.3390/md8112848 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yan, Pengcheng
Deng, Zhiwei
van Ofwegen, Leen
Proksch, Peter
Lin, Wenhan
Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum
title Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum
title_full Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum
title_fullStr Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum
title_full_unstemmed Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum
title_short Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum
title_sort lobophytones o–t, new biscembranoids and cembranoid from soft coral lobophytum pauciflorum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996179/
https://www.ncbi.nlm.nih.gov/pubmed/21139847
http://dx.doi.org/10.3390/md8112848
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