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Functional Brain Network Changes Associated with Maintenance of Cognitive Function in Multiple Sclerosis

In multiple sclerosis (MS) functional changes in connectivity due to cortical reorganization could lead to cognitive impairment (CI), or reflect a re-adjustment to reduce the clinical effects of widespread tissue damage. Such alterations in connectivity could result in changes in neural activation a...

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Autores principales: Helekar, Santosh A., Shin, Jae C., Mattson, Brandi J., Bartley, Krystle, Stosic, Milena, Saldana-King, Toni, Montague, P. Read, Hutton, George J.
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996259/
https://www.ncbi.nlm.nih.gov/pubmed/21152340
http://dx.doi.org/10.3389/fnhum.2010.00219
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author Helekar, Santosh A.
Shin, Jae C.
Mattson, Brandi J.
Bartley, Krystle
Stosic, Milena
Saldana-King, Toni
Montague, P. Read
Hutton, George J.
author_facet Helekar, Santosh A.
Shin, Jae C.
Mattson, Brandi J.
Bartley, Krystle
Stosic, Milena
Saldana-King, Toni
Montague, P. Read
Hutton, George J.
author_sort Helekar, Santosh A.
collection PubMed
description In multiple sclerosis (MS) functional changes in connectivity due to cortical reorganization could lead to cognitive impairment (CI), or reflect a re-adjustment to reduce the clinical effects of widespread tissue damage. Such alterations in connectivity could result in changes in neural activation as assayed by executive function tasks. We examined cognitive function in MS patients with mild to moderate CI and age-matched controls. We evaluated brain activity using functional magnetic resonance imaging (fMRI) during the successful performance of the Wisconsin card sorting (WCS) task by MS patients, showing compensatory maintenance of normal function, as measured by response latency and error rate. To assess changes in functional connectivity throughout the brain, we performed a global functional brain network analysis by computing voxel-by-voxel correlations on the fMRI time series data and carrying out a hierarchical cluster analysis. We found that during the WCS task there is a significant reduction in the number of smaller size brain functional networks, and a change in the brain areas representing the nodes of these networks in MS patients compared to age-matched controls. There is also a concomitant increase in the strength of functional connections between brain loci separated at intermediate-scale distances in these patients. These functional alterations might reflect compensatory neuroplastic reorganization underlying maintenance of relatively normal cognitive function in the face of white matter lesions and cortical atrophy produced by MS.
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spelling pubmed-29962592010-12-09 Functional Brain Network Changes Associated with Maintenance of Cognitive Function in Multiple Sclerosis Helekar, Santosh A. Shin, Jae C. Mattson, Brandi J. Bartley, Krystle Stosic, Milena Saldana-King, Toni Montague, P. Read Hutton, George J. Front Hum Neurosci Neuroscience In multiple sclerosis (MS) functional changes in connectivity due to cortical reorganization could lead to cognitive impairment (CI), or reflect a re-adjustment to reduce the clinical effects of widespread tissue damage. Such alterations in connectivity could result in changes in neural activation as assayed by executive function tasks. We examined cognitive function in MS patients with mild to moderate CI and age-matched controls. We evaluated brain activity using functional magnetic resonance imaging (fMRI) during the successful performance of the Wisconsin card sorting (WCS) task by MS patients, showing compensatory maintenance of normal function, as measured by response latency and error rate. To assess changes in functional connectivity throughout the brain, we performed a global functional brain network analysis by computing voxel-by-voxel correlations on the fMRI time series data and carrying out a hierarchical cluster analysis. We found that during the WCS task there is a significant reduction in the number of smaller size brain functional networks, and a change in the brain areas representing the nodes of these networks in MS patients compared to age-matched controls. There is also a concomitant increase in the strength of functional connections between brain loci separated at intermediate-scale distances in these patients. These functional alterations might reflect compensatory neuroplastic reorganization underlying maintenance of relatively normal cognitive function in the face of white matter lesions and cortical atrophy produced by MS. Frontiers Research Foundation 2010-11-22 /pmc/articles/PMC2996259/ /pubmed/21152340 http://dx.doi.org/10.3389/fnhum.2010.00219 Text en Copyright © 2010 Helekar, Shin, Mattson, Bartley, Stosic, Saldana-King, Montague and Hutton. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Helekar, Santosh A.
Shin, Jae C.
Mattson, Brandi J.
Bartley, Krystle
Stosic, Milena
Saldana-King, Toni
Montague, P. Read
Hutton, George J.
Functional Brain Network Changes Associated with Maintenance of Cognitive Function in Multiple Sclerosis
title Functional Brain Network Changes Associated with Maintenance of Cognitive Function in Multiple Sclerosis
title_full Functional Brain Network Changes Associated with Maintenance of Cognitive Function in Multiple Sclerosis
title_fullStr Functional Brain Network Changes Associated with Maintenance of Cognitive Function in Multiple Sclerosis
title_full_unstemmed Functional Brain Network Changes Associated with Maintenance of Cognitive Function in Multiple Sclerosis
title_short Functional Brain Network Changes Associated with Maintenance of Cognitive Function in Multiple Sclerosis
title_sort functional brain network changes associated with maintenance of cognitive function in multiple sclerosis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996259/
https://www.ncbi.nlm.nih.gov/pubmed/21152340
http://dx.doi.org/10.3389/fnhum.2010.00219
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