Kif3a Deficiency Reverses the Skeletal Abnormalities in Pkd1 Deficient Mice by Restoring the Balance Between Osteogenesis and Adipogenesis

Pkd1 localizes to primary cilia in osteoblasts and osteocytes. Targeted deletion of Pkd1 in osteoblasts results in osteopenia and abnormalities in Runx2-mediated osteoblast development. Kif3a, an intraflagellar transport protein required for cilia function, is also expressed in osteoblasts. To asses...

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Detalles Bibliográficos
Autores principales: Qiu, Ni, Cao, Li, David, Valentin, Quarles, L. Darryl, Xiao, Zhousheng
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996304/
https://www.ncbi.nlm.nih.gov/pubmed/21151991
http://dx.doi.org/10.1371/journal.pone.0015240

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