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Rapid End-Point Quantitation of Prion Seeding Activity with Sensitivity Comparable to Bioassays

A major problem for the effective diagnosis and management of prion diseases is the lack of rapid high-throughput assays to measure low levels of prions. Such measurements have typically required prolonged bioassays in animals. Highly sensitive, but generally non-quantitative, prion detection method...

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Detalles Bibliográficos
Autores principales:	Wilham, Jason M., Orrú, Christina D., Bessen, Richard A., Atarashi, Ryuichiro, Sano, Kazunori, Race, Brent, Meade-White, Kimberly D., Taubner, Lara M., Timmes, Andrew, Caughey, Byron
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996325/ https://www.ncbi.nlm.nih.gov/pubmed/21152012 http://dx.doi.org/10.1371/journal.ppat.1001217

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