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The DNA Damage Response Pathway Contributes to the Stability of Chromosome III Derivatives Lacking Efficient Replicators

In eukaryotic chromosomes, DNA replication initiates at multiple origins. Large inter-origin gaps arise when several adjacent origins fail to fire. Little is known about how cells cope with this situation. We created a derivative of Saccharomyces cerevisiae chromosome III lacking all efficient origi...

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Detalles Bibliográficos
Autores principales:	Theis, James F., Irene, Carmela, Dershowitz, Ann, Brost, Renee L., Tobin, Michael L., di Sanzo, Fabiana M., Wang, Jian-Ying, Boone, Charles, Newlon, Carol S.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996327/ https://www.ncbi.nlm.nih.gov/pubmed/21151954 http://dx.doi.org/10.1371/journal.pgen.1001227

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