Human IRGM Regulates Autophagy and Its Cell-Autonomous Immunity Functions Through Mitochondria

IRGM, a human immunity related GTPase, confers autophagic defense against intracellular pathogens by an unknown mechanism. Here we report the unexpected mode of IRGM action. IRGM showed differential affinity for mitochondrial lipid cardiolipin, translocated to mitochondria, affected mitochondrial fi...

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Detalles Bibliográficos
Autores principales: Singh, Sudha B., Ornatowski, Wojciech, Vergne, Isabelle, Naylor, John, Delgado, Monica, Roberts, Esteban, Ponpuak, Marisa, Master, Sharon, Pilli, Manohar, White, Eileen, Komatsu, Masaaki, Deretic, Vojo
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996476/
https://www.ncbi.nlm.nih.gov/pubmed/21102437
http://dx.doi.org/10.1038/ncb2119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996476/
https://www.ncbi.nlm.nih.gov/pubmed/21102437
http://dx.doi.org/10.1038/ncb2119

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