Cargando…
Human IRGM Regulates Autophagy and Its Cell-Autonomous Immunity Functions Through Mitochondria
IRGM, a human immunity related GTPase, confers autophagic defense against intracellular pathogens by an unknown mechanism. Here we report the unexpected mode of IRGM action. IRGM showed differential affinity for mitochondrial lipid cardiolipin, translocated to mitochondria, affected mitochondrial fi...
Autores principales: | Singh, Sudha B., Ornatowski, Wojciech, Vergne, Isabelle, Naylor, John, Delgado, Monica, Roberts, Esteban, Ponpuak, Marisa, Master, Sharon, Pilli, Manohar, White, Eileen, Komatsu, Masaaki, Deretic, Vojo |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996476/ https://www.ncbi.nlm.nih.gov/pubmed/21102437 http://dx.doi.org/10.1038/ncb2119 |
Ejemplares similares
-
Autophagy of intracellular microbes and mitochondria: two sides of the same coin?
por: Deretic, Vojo
Publicado: (2010) -
Tuberculosis Toxin Blocking Phagosome Maturation Inhibits a Novel Ca(2+)/Calmodulin-PI3K hVPS34 Cascade
por: Vergne, Isabelle, et al.
Publicado: (2003) -
Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins
por: Kumar, Suresh, et al.
Publicado: (2018) -
Autophagy and immunity
por: Deretic, Vojo
Publicado: (2020) -
Mammalian Atg8 proteins and autophagy factor IRGM control mTOR and
TFEB at a regulatory node critical for response to pathogens
por: Kumar, Suresh, et al.
Publicado: (2020)