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Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves

Antinociceptive and anti-inflammatory activities of the Muehlenbeckia platyclada leaves’ ethanol extract were investigated in animal models. The extract (p.o.) reduced the number of abdominal contortions induced by acetic acid by 21.57% (400 mg/kg). After intraplantar injection of formalin, a dose o...

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Autores principales: Fagundes, Leopoldina Leonor, Vieira, Glauciemar Del-Vechio, de Pinho, José de Jesus R. G., Yamamoto, Célia Hitomi, Alves, Maria Silvana, Stringheta, Paulo César, de Sousa, Orlando Vieira
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996782/
https://www.ncbi.nlm.nih.gov/pubmed/21152311
http://dx.doi.org/10.3390/ijms11103942
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author Fagundes, Leopoldina Leonor
Vieira, Glauciemar Del-Vechio
de Pinho, José de Jesus R. G.
Yamamoto, Célia Hitomi
Alves, Maria Silvana
Stringheta, Paulo César
de Sousa, Orlando Vieira
author_facet Fagundes, Leopoldina Leonor
Vieira, Glauciemar Del-Vechio
de Pinho, José de Jesus R. G.
Yamamoto, Célia Hitomi
Alves, Maria Silvana
Stringheta, Paulo César
de Sousa, Orlando Vieira
author_sort Fagundes, Leopoldina Leonor
collection PubMed
description Antinociceptive and anti-inflammatory activities of the Muehlenbeckia platyclada leaves’ ethanol extract were investigated in animal models. The extract (p.o.) reduced the number of abdominal contortions induced by acetic acid by 21.57% (400 mg/kg). After intraplantar injection of formalin, a dose of 400 mg/kg (p.o.) inhibited the time spent paw licking in the first phase (26.43%), while the second phase was inhibited by 10.90 and 36.65% at the doses of 200 and 400 mg/kg, respectively. The extract (p.o.) increased the reaction time on a hot plate at a dose of 400 mg/kg (32.68 and 40.30%) after 60 and 90 minutes of treatment, respectively. The paw edema was reduced by extract (p.o.) at doses of 100 (15.46 and 16.67%), 200 (22.68 and 25.64%) and 400 mg/kg (29.50 and 37.33%) after 3 to 4 h of carrageenan application, respectively. Doses of 100, 200 and 400 mg/kg (p.o.), administered 4 h after the carrageenan injection, reduced the exudate volume (11.28, 21.54 and 45.13%), while leukocyte migration was reduced by 21.21 and 29.70% at the doses of 200 and 400 mg/kg, respectively. These results indicate that the ethanol extract from M. platyclada may constitute a potential target for the discovery of new molecules with antinociceptive and anti-inflammatory activities that can be explored for their therapeutic use.
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spelling pubmed-29967822010-12-08 Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves Fagundes, Leopoldina Leonor Vieira, Glauciemar Del-Vechio de Pinho, José de Jesus R. G. Yamamoto, Célia Hitomi Alves, Maria Silvana Stringheta, Paulo César de Sousa, Orlando Vieira Int J Mol Sci Article Antinociceptive and anti-inflammatory activities of the Muehlenbeckia platyclada leaves’ ethanol extract were investigated in animal models. The extract (p.o.) reduced the number of abdominal contortions induced by acetic acid by 21.57% (400 mg/kg). After intraplantar injection of formalin, a dose of 400 mg/kg (p.o.) inhibited the time spent paw licking in the first phase (26.43%), while the second phase was inhibited by 10.90 and 36.65% at the doses of 200 and 400 mg/kg, respectively. The extract (p.o.) increased the reaction time on a hot plate at a dose of 400 mg/kg (32.68 and 40.30%) after 60 and 90 minutes of treatment, respectively. The paw edema was reduced by extract (p.o.) at doses of 100 (15.46 and 16.67%), 200 (22.68 and 25.64%) and 400 mg/kg (29.50 and 37.33%) after 3 to 4 h of carrageenan application, respectively. Doses of 100, 200 and 400 mg/kg (p.o.), administered 4 h after the carrageenan injection, reduced the exudate volume (11.28, 21.54 and 45.13%), while leukocyte migration was reduced by 21.21 and 29.70% at the doses of 200 and 400 mg/kg, respectively. These results indicate that the ethanol extract from M. platyclada may constitute a potential target for the discovery of new molecules with antinociceptive and anti-inflammatory activities that can be explored for their therapeutic use. Molecular Diversity Preservation International (MDPI) 2010-10-15 /pmc/articles/PMC2996782/ /pubmed/21152311 http://dx.doi.org/10.3390/ijms11103942 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Fagundes, Leopoldina Leonor
Vieira, Glauciemar Del-Vechio
de Pinho, José de Jesus R. G.
Yamamoto, Célia Hitomi
Alves, Maria Silvana
Stringheta, Paulo César
de Sousa, Orlando Vieira
Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves
title Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves
title_full Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves
title_fullStr Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves
title_full_unstemmed Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves
title_short Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves
title_sort pharmacological proprieties of the ethanol extract of muehlenbeckia platyclada (f. muell.) meisn. leaves
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996782/
https://www.ncbi.nlm.nih.gov/pubmed/21152311
http://dx.doi.org/10.3390/ijms11103942
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