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Molecular Modeling Studies of 4,5-Dihydro-1H-pyrazolo[4,3-h] quinazoline Derivatives as Potent CDK2/Cyclin A Inhibitors Using 3D-QSAR and Docking

CDK2/cyclin A has appeared as an attractive drug targets over the years with diverse therapeutic potentials. A computational strategy based on comparative molecular fields analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) followed by molecular docking studies were perfo...

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Detalles Bibliográficos
Autores principales:	Ai, Yong, Wang, Shao-Teng, Sun, Ping-Hua, Song, Fa-Jun
Formato:	Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996803/ https://www.ncbi.nlm.nih.gov/pubmed/21152296 http://dx.doi.org/10.3390/ijms11103705

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