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Molecular Dynamics Simulation Studies of GLUT4: Substrate-Free and Substrate-Induced Dynamics and ATP-Mediated Glucose Transport Inhibition

BACKGROUND: Glucose transporter 4 (GLUT4) is an insulin facilitated glucose transporter that plays an important role in maintaining blood glucose homeostasis. GLUT4 is sequestered into intracellular vesicles in unstimulated cells and translocated to the plasma membrane by various stimuli. Understand...

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Detalles Bibliográficos
Autores principales: Mohan, Suma, Sheena, Aswathy, Poulose, Ninu, Anilkumar, Gopalakrishnapillai
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997047/
https://www.ncbi.nlm.nih.gov/pubmed/21151967
http://dx.doi.org/10.1371/journal.pone.0014217