Cargando…

Molecular Dynamics Simulation Studies of GLUT4: Substrate-Free and Substrate-Induced Dynamics and ATP-Mediated Glucose Transport Inhibition

BACKGROUND: Glucose transporter 4 (GLUT4) is an insulin facilitated glucose transporter that plays an important role in maintaining blood glucose homeostasis. GLUT4 is sequestered into intracellular vesicles in unstimulated cells and translocated to the plasma membrane by various stimuli. Understand...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mohan, Suma, Sheena, Aswathy, Poulose, Ninu, Anilkumar, Gopalakrishnapillai
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997047/ https://www.ncbi.nlm.nih.gov/pubmed/21151967 http://dx.doi.org/10.1371/journal.pone.0014217

Ejemplares similares

Elucidation of the Glucose Transport Pathway in Glucose Transporter 4 via Steered Molecular Dynamics Simulations
por: Sheena, Aswathy, et al.
Publicado: (2011)

Molecular Dynamics Simulations of the Human Glucose Transporter GLUT1
por: Park, Min-Sun
Publicado: (2015)

Substrate Modulated Dynamics of the ADP/ATP Transporter Revealed by NMR Relaxation Dispersion
por: Brüschweiler, Sven, et al.
Publicado: (2015)

Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations
por: Gabrielsen, Mari, et al.
Publicado: (2011)

Observing spontaneous, accelerated substrate binding in molecular dynamics simulations of glutamate transporters
por: Wang, Jiali, et al.
Publicado: (2021)

Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes
por: Steinbusch, Laura K. M., et al.
Publicado: (2011)

Substrate-induced conformational dynamics of the dopamine transporter
por: Nielsen, Anne Kathrine, et al.
Publicado: (2019)

Targeting of GLUT5 for Transporter-Mediated Drug-Delivery Is Contingent upon Substrate Hydrophilicity
por: Nahrjou, Nazanin, et al.
Publicado: (2021)

Insights into Substrate and Inhibitor Selectivity among Human GLUT Transporters through Comparative Modeling and Molecular Docking
por: Ferreira, Rafaela Salgado, et al.
Publicado: (2019)

Nonmitochondrial ATP/ADP Transporters Accept Phosphate as Third Substrate
por: Trentmann, Oliver, et al.
Publicado: (2008)

ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled
por: Singh, Himansha, et al.
Publicado: (2016)

Glucose Metabolism and Dynamics of Facilitative Glucose Transporters (GLUTs) under the Influence of Heat Stress in Dairy Cattle
por: Abbas, Zaheer, et al.
Publicado: (2020)

Molecular Dynamics Simulation of the Allosteric Regulation of eIF4A Protein from the Open to Closed State, Induced by ATP and RNA Substrates
por: Meng, Hongqing, et al.
Publicado: (2014)

Case-Control Analysis of SNPs in GLUT4, RBP4 and STRA6: Association of SNPs in STRA6 with Type 2 Diabetes in a South Indian Population
por: Nair, Anup Kumar, et al.
Publicado: (2010)

Development of Glucose Transporter (GLUT) Inhibitors
por: Reckzeh, Elena S., et al.
Publicado: (2019)

Expression of the glucose transporters GLUT1, GLUT3, GLUT4 and GLUT12 in human cancer cells
por: Barron, Carly, et al.
Publicado: (2012)

Molecular Docking Simulations Provide Insights in the Substrate Binding Sites and Possible Substrates of the ABCC6 Transporter
por: Hosen, Mohammad Jakir, et al.
Publicado: (2014)

Molecular Dynamics Simulations of Substrate Hydrophilicity and Confinement Effects in Capped Nafion Films
por: Sengupta, Soumyadipta, et al.
Publicado: (2018)

Exploration of the Substrate Preference of Lysine Methyltransferase SMYD3 by Molecular Dynamics Simulations
por: Sun, Jixue, et al.
Publicado: (2019)

Expression of GLUT1 and GLUT3 Glucose Transporters in Endometrial and Breast Cancers
por: Krzeslak, Anna, et al.
Publicado: (2012)

Conformational dynamics of the human serotonin transporter during substrate and drug binding
por: Möller, Ingvar R., et al.
Publicado: (2019)

Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases
por: Zelnik, Iris D., et al.
Publicado: (2023)

Molecular dynamics simulation of the amorphous graphite-like membrane deposited on ideal graphite substrate
por: Xiaoguo, Cao, et al.
Publicado: (2023)

Glucose transporters GLUT1, GLUT3, and GLUT4 have different effects on osteoblast proliferation and metabolism
por: Arponen, Milja, et al.
Publicado: (2022)

Small Substrate Transport and Mechanism of a Molybdate ATP Binding Cassette Transporter in a Lipid Environment
por: Rice, Austin J., et al.
Publicado: (2014)

Selecting for Altered Substrate Specificity Reveals the Evolutionary Flexibilityof ATP-Binding Cassette Transporters
por: Srikant, Sriram, et al.
Publicado: (2020)

Substrate-modulated gating dynamics in a Na(+)-coupled neurotransmitter transporter homolog
por: Zhao, Yongfang, et al.
Publicado: (2011)

Substrate-dependent dynamics of the multidrug efflux transporter AcrB of Escherichia coli
por: Yamamoto, Kentaro, et al.
Publicado: (2016)

Osmotic Water Transport with Glucose in GLUT2 and SGLT
por: Naftalin, Richard J.
Publicado: (2008)

Molecular Dynamics Simulations Study of the Interactions between Human Dipeptidyl-Peptidase III and Two Substrates
por: Zhang, Shitao, et al.
Publicado: (2021)

Placental expression of glucose transporters GLUT‐1, GLUT‐3, GLUT‐8 and GLUT‐12 in pregnancies complicated by gestational and type 1 diabetes mellitus
por: Stanirowski, Paweł Jan, et al.
Publicado: (2021)

Translocation of the glucose transporter (GLUT4) to the cell surface in permeabilized 3T3-L1 adipocytes: effects of ATP insulin, and GTP gamma S and localization of GLUT4 to clathrin lattices
Publicado: (1992)

Conformational and dynamic plasticity in substrate-binding proteins underlies selective transport in ABC importers
por: de Boer, Marijn, et al.
Publicado: (2019)

Na(+)-dependent gate dynamics and electrostatic attraction ensure substrate coupling in glutamate transporters
por: Alleva, C., et al.
Publicado: (2020)

ATP-independent substrate recruitment to proteasomal degradation in mycobacteria
por: von Rosen, Tatjana, et al.
Publicado: (2023)

Functional Expression of the Human Glucose Transporters GLUT2 and GLUT3 in Yeast Offers Novel Screening Systems for GLUT-Targeting Drugs
por: Schmidl, Sina, et al.
Publicado: (2021)

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate
por: Duan, Xiaowen, et al.
Publicado: (2022)

Calculation of substrate binding affinities for a bacterial GH78 rhamnosidase through molecular dynamics simulations
por: Grandits, Melanie, et al.
Publicado: (2013)

The structural basis of unique substrate recognition by Plasmodium thymidylate kinase: Molecular dynamics simulation and inhibitory studies
por: Kandeel, Mahmoud, et al.
Publicado: (2019)

Molecular Dynamics Study on the Reaction of RDX Molecule with Si Substrate
por: Xu, Wei-Sen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_albe2qc48lqr598cg5ntf2dvgk