Cargando…

Metabolomic Characterization of Human Prostate Cancer Bone Metastases Reveals Increased Levels of Cholesterol

BACKGROUND: Metastasis to the bone is one clinically important features of prostate cancer (PCa). Current diagnostic methods cannot predict metastatic PCa at a curable stage of the disease. Identification of metabolic pathways involved in the growth of bone metastases therefore has the potential to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thysell, Elin, Surowiec, Izabella, Hörnberg, Emma, Crnalic, Sead, Widmark, Anders, Johansson, Annika I., Stattin, Pär, Bergh, Anders, Moritz, Thomas, Antti, Henrik, Wikström, Pernilla
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997052/ https://www.ncbi.nlm.nih.gov/pubmed/21151972 http://dx.doi.org/10.1371/journal.pone.0014175

Ejemplares similares

Expression of Androgen Receptor Splice Variants in Prostate Cancer Bone Metastases is Associated with Castration-Resistance and Short Survival
por: Hörnberg, Emma, et al.
Publicado: (2011)

Characterization of Prostate Cancer Bone Metastases According to Expression Levels of Steroidogenic Enzymes and Androgen Receptor Splice Variants
por: Jernberg, Emma, et al.
Publicado: (2013)

Gene expression profiles define molecular subtypes of prostate cancer bone metastases with different outcomes and morphology traceable back to the primary tumor
por: Thysell, Elin, et al.
Publicado: (2019)

Bone Cell Activity in Clinical Prostate Cancer Bone Metastasis and Its Inverse Relation to Tumor Cell Androgen Receptor Activity
por: Nordstrand, Annika, et al.
Publicado: (2018)

Investigating microRNA Profiles in Prostate Cancer Bone Metastases and Functional Effects of microRNA-23c and microRNA-4328
por: Järemo, Helena, et al.
Publicado: (2023)

Epithelial and Stromal Characteristics of Primary Tumors Predict the Bone Metastatic Subtype of Prostate Cancer and Patient Survival after Androgen-Deprivation Therapy
por: Wikström, Pernilla, et al.
Publicado: (2022)

Outcome after surgery for metastatic spinal cord compression in 54 patients with prostate cancer
por: Crnalic, Sead, et al.
Publicado: (2012)

A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer
por: Ylitalo, Erik Bovinder, et al.
Publicado: (2021)

A Novel Radiographic Pattern Related to Poor Prognosis in Patients with Prostate Cancer with Metastatic Spinal Cord Compression
por: Wänman, Johan, et al.
Publicado: (2022)

Constrained randomization and multivariate effect projections improve information extraction and biomarker pattern discovery in metabolomics studies involving dependent samples
por: Jonsson, Pär, et al.
Publicado: (2015)

Extratumoral Heme Oxygenase-1 (HO-1) Expressing Macrophages Likely Promote Primary and Metastatic Prostate Tumor Growth
por: Halin Bergström, Sofia, et al.
Publicado: (2016)

Inhibition of the insulin-like growth factor-1 receptor potentiates acute effects of castration in a rat model for prostate cancer growth in bone
por: Nordstrand, Annika, et al.
Publicado: (2017)

Clinical and biological relevance of the transcriptomic‐based prostate cancer metastasis subtypes MetA‐C
por: Thysell, Elin, et al.
Publicado: (2021)

Comprehensive metabolomics analysis of prostate cancer tissue in relation to tumor aggressiveness and TMPRSS2-ERG fusion status
por: Dudka, Ilona, et al.
Publicado: (2020)

Marked response to cabazitaxel in prostate cancer xenografts expressing androgen receptor variant 7 and reversion of acquired resistance by anti‐androgens
por: Ylitalo, Erik Bovinder, et al.
Publicado: (2019)

Metastatic spinal cord compression as the first sign of malignancy: Outcome after surgery in 69 patients
por: Wänman, Johan, et al.
Publicado: (2017)

High Lysyl Oxidase (LOX) in the Non-Malignant Prostate Epithelium Predicts a Poor Outcome in Prostate Cancer Patient Managed by Watchful Waiting
por: Nilsson, Maria, et al.
Publicado: (2015)

Immunoreactivity for prostate specific antigen and Ki67 differentiates subgroups of prostate cancer related to outcome
por: Hammarsten, Peter, et al.
Publicado: (2019)

Extracellular Vesicles from Metastatic Rat Prostate Tumors Prime the Normal Prostate Tissue to Facilitate Tumor Growth
por: Halin Bergström, Sofia, et al.
Publicado: (2016)

High Monocyte Count and Expression of S100A9 and S100A12 in Peripheral Blood Mononuclear Cells Are Associated with Poor Outcome in Patients with Metastatic Prostate Cancer
por: Åberg, Anna-Maja, et al.
Publicado: (2021)

Validated and Predictive Processing of Gas Chromatography-Mass Spectrometry Based Metabolomics Data for Large Scale Screening Studies, Diagnostics and Metabolite Pattern Verification
por: Thysell, Elin, et al.
Publicado: (2012)

High Caveolin-1 Expression in Tumor Stroma Is Associated with a Favourable Outcome in Prostate Cancer Patients Managed by Watchful Waiting
por: Hammarsten, Peter, et al.
Publicado: (2016)

Metabolomic profiles of intact tissues reflect clinically relevant prostate cancer subtypes
por: Dudka, Ilona, et al.
Publicado: (2023)

Population-based study on use of chemotherapy in men with castration resistant prostate cancer
por: Lissbrant, Ingela Franck, et al.
Publicado: (2013)

Secreted Factors from Colorectal and Prostate Cancer Cells Skew the Immune Response in Opposite Directions
por: Lundholm, Marie, et al.
Publicado: (2015)

Inhibition of the Insulin-Like Growth Factor-1 Receptor Enhances Effects of Simvastatin on Prostate Cancer Cells in Co-Culture with Bone
por: Nordstrand, Annika, et al.
Publicado: (2013)

Clinical relevance of androgen receptor alterations in prostate cancer
por: Jernberg, Emma, et al.
Publicado: (2017)

Uncemented monoblock trabecular metal posterior stabilized high-flex total knee arthroplasty: similar pattern of migration to the cruciate-retaining design — a prospective radiostereometric analysis (RSA) and clinical evaluation of 40 patients (49 knees) 60 years or younger with 9 years’ follow-up
por: Wojtowicz, Radoslaw, et al.
Publicado: (2019)

Aggressive rat prostate tumors reprogram the benign parts of the prostate and regional lymph nodes prior to metastasis
por: Strömvall, Kerstin, et al.
Publicado: (2017)

Population‐based study of long‐term functional outcomes after prostate cancer treatment
por: Carlsson, Sigrid, et al.
Publicado: (2015)

Prostate specific antigen for early detection of prostate cancer: longitudinal study
por: Holmström, Benny, et al.
Publicado: (2009)

Highly aggressive rat prostate tumors rapidly precondition regional lymph nodes for subsequent metastatic growth
por: Strömvall, Kerstin, et al.
Publicado: (2017)

Prostate Tumor-Derived Exosomes Down-Regulate NKG2D Expression on Natural Killer Cells and CD8(+) T Cells: Mechanism of Immune Evasion
por: Lundholm, Marie, et al.
Publicado: (2014)

(1)H HRMAS NMR Derived Bio-markers Related to Tumor Grade, Tumor Cell Fraction, and Cell Proliferation in Prostate Tissue Samples
por: Stenman, Katarina, et al.
Publicado: (2011)

The accuracy of digital templating in cementless total hip arthroplasty in dysplastic hips
por: Kristoffersson, Emelie, et al.
Publicado: (2021)

Multivariate strategy for the sample selection and integration of multi-batch data in metabolomics
por: Surowiec, Izabella, et al.
Publicado: (2017)

Prostate cancer polygenic risk score and prediction of lethal prostate cancer
por: Klein, Robert J., et al.
Publicado: (2022)

High‐grade tumours promote growth of other less‐malignant tumours in the same prostate
por: Halin Bergström, Sofia, et al.
Publicado: (2021)

Stromal PDGFRβ Expression in Prostate Tumors and Non-Malignant Prostate Tissue Predicts Prostate Cancer Survival
por: Hägglöf, Christina, et al.
Publicado: (2010)

Socioeconomic variables and fracture risk in children and adolescents: a population-based study from northern Sweden
por: Hedström, Erik, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_niqjf99uu56uebqn85m35gq9hf