Cargando…

Epigenetic Silencing of Peroxisome Proliferator-Activated Receptor γ Is a Biomarker for Colorectal Cancer Progression and Adverse Patients' Outcome

The relationship between peroxisome proliferator-activated receptor γ (PPARG) expression and epigenetic changes occurring in colorectal-cancer pathogenesis is largely unknown. We investigated whether PPARG is epigenetically regulated in colorectal cancer (CRC) progression. PPARG expression was asses...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pancione, Massimo, Sabatino, Lina, Fucci, Alessandra, Carafa, Vincenzo, Nebbioso, Angela, Forte, Nicola, Febbraro, Antonio, Parente, Domenico, Ambrosino, Concetta, Normanno, Nicola, Altucci, Lucia, Colantuoni, Vittorio
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997072/ https://www.ncbi.nlm.nih.gov/pubmed/21151932 http://dx.doi.org/10.1371/journal.pone.0014229

Ejemplares similares

Correction: Epigenetic Silencing of Peroxisome Proliferator-Activated Receptor γ Is a Biomarker for Colorectal Cancer Progression and Adverse Patients' Outcome
por: Pancione, Massimo, et al.
Publicado: (2011)

PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis
por: Sabatino, Lina, et al.
Publicado: (2012)

The Role of Peroxisome Proliferator-Activated Receptors in the Esophageal, Gastric, and Colorectal Cancer
por: Fucci, Alessandra, et al.
Publicado: (2012)

Immune Escape Mechanisms in Colorectal Cancer Pathogenesis and Liver Metastasis
por: Pancione, Massimo, et al.
Publicado: (2014)

Right-sided rhabdoid colorectal tumors might be related to the Serrated Pathway
por: Pancione, Massimo, et al.
Publicado: (2013)

Genetic and Epigenetic Events Generate Multiple Pathways in Colorectal Cancer Progression
por: Pancione, Massimo, et al.
Publicado: (2012)

Sirtuins and Disease: The Road Ahead
por: Carafa, Vincenzo, et al.
Publicado: (2012)

Dual Tumor Suppressor and Tumor Promoter Action of Sirtuins in Determining Malignant Phenotype
por: Carafa, Vincenzo, et al.
Publicado: (2019)

NAA60 (HAT4): the newly discovered bi-functional Golgi member of the acetyltransferase family
por: Donnarumma, Federica, et al.
Publicado: (2022)

Ensemble of Gene Signatures Identifies Novel Biomarkers in Colorectal Cancer Activated through PPARγ and TNFα Signaling
por: Pagnotta, Stefano Maria, et al.
Publicado: (2013)

Gene Transactivation and Transrepression in MYC-Driven Cancers
por: Scafuro, Marika, et al.
Publicado: (2021)

Cancer epigenetics: Moving forward
por: Nebbioso, Angela, et al.
Publicado: (2018)

Retraction: Epigenetic Silencing of Peroxisome Proliferator-Activated Receptor γ Is a Biomarker for Colorectal Cancer Progression and Adverse Patients’ Outcome
Publicado: (2019)

Marine-Derived Secondary Metabolites as Promising Epigenetic Bio-Compounds for Anticancer Therapy
por: Conte, Mariarosaria, et al.
Publicado: (2020)

SIRT1 Activation by Natural Phytochemicals: An Overview
por: Iside, Concetta, et al.
Publicado: (2020)

Epigenetic Activation and Silencing of the Gene that Encodes IFN-γ
por: Aune, Thomas M., et al.
Publicado: (2013)

Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists
por: Sabatino, Lina, et al.
Publicado: (2019)

Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer
por: Giordano, Guido, et al.
Publicado: (2015)

Histone deacetylase inhibitors: clinical implications for hematological malignancies
por: Tambaro, Francesco Paolo, et al.
Publicado: (2010)

The Role of Necroptosis: Biological Relevance and Its Involvement in Cancer
por: Della Torre, Laura, et al.
Publicado: (2021)

Trifolium Repens Blocks Proliferation in Chronic Myelogenous Leukemia via the BCR-ABL/STAT5 Pathway
por: Sarno, Federica, et al.
Publicado: (2020)

Deregulation of Cell Death in Cancer: Recent Highlights
por: Carafa, Vincenzo, et al.
Publicado: (2020)

CBX2 shapes chromatin accessibility promoting AML via p38 MAPK signaling pathway
por: Del Gaudio, Nunzio, et al.
Publicado: (2022)

“Stockpile” of Slight Transcriptomic Changes Determines the Indirect Genotoxicity of Low-Dose BPA in Thyroid Cells
por: Porreca, Immacolata, et al.
Publicado: (2016)

SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism
por: Varghese, Benluvankar, et al.
Publicado: (2023)

Comparative Phytochemical Characterization, Genetic Profile, and Antiproliferative Activity of Polyphenol-Rich Extracts from Pigmented Tubers of Different Solanum tuberosum Varieties
por: De Masi, Luigi, et al.
Publicado: (2020)

Peroxisome Proliferator-Activated Receptor-γ as a Target and Regulator of Epigenetic Mechanisms in Nonalcoholic Fatty Liver Disease
por: Zaiou, Mohamed
Publicado: (2023)

DOT1L: a key target in normal chromatin remodelling and in mixed-lineage leukaemia treatment
por: Sarno, Federica, et al.
Publicado: (2019)

A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability
por: Vasaturo, Michele, et al.
Publicado: (2017)

Single-cell proteo-genomic reveals a comprehensive map of centrosome-associated spliceosome components
por: Cerulo, Luigi, et al.
Publicado: (2023)

Peroxisome Proliferator-Activated Receptor-γ in Thyroid Autoimmunity
por: Ferrari, Silvia Martina, et al.
Publicado: (2015)

Peroxisome Proliferator-Activated Receptors (PPAR)γ Agonists as Master Modulators of Tumor Tissue
por: Heudobler, Daniel, et al.
Publicado: (2018)

The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukaemia cells
por: Cellai, C, et al.
Publicado: (2012)

Time-resolved analysis of DNA-protein interactions in living cells by UV laser pulses
por: Nebbioso, Angela, et al.
Publicado: (2017)

Recent Advancement in Anticancer Compounds from Marine Organisms: Approval, Use and Bioinformatic Approaches to Predict New Targets
por: Santaniello, Giovanna, et al.
Publicado: (2022)

Cancer-Associated Immune Resistance and Evasion of Immune Surveillance in Colorectal Cancer
por: Parcesepe, Pietro, et al.
Publicado: (2016)

Nickel and Epigenetic Gene Silencing
por: Sun, Hong, et al.
Publicado: (2013)

Epigenetic silencing in transgenic plants
por: Rajeevkumar, Sarma, et al.
Publicado: (2015)

Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity
por: Chiurazzi, Martina, et al.
Publicado: (2020)

Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence
por: Scisciola, Lucia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_s77kbasu2a189bt389fap980gu