The Type of Responder T-Cell Has a Significant Impact in a Human In Vitro Suppression Assay

BACKGROUND: In type 1 diabetes (T1D), a prototypic autoimmune disease, effector T cells destroy beta cells. Normally, CD4(+)CD25(+high), or natural regulatory T cells (Tregs), counter this assault. In autoimmunity, the failure to suppress CD4(+)CD25(low) T cells is important for disease development....

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Detalles Bibliográficos
Autores principales: Jana, Srikanta, Campbell, Hope, Woodliff, Jeffrey, Waukau, Jill, Jailwala, Parthav, Ghorai, Jugal, Ghosh, Soumitra, Glisic, Sanja
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997082/
https://www.ncbi.nlm.nih.gov/pubmed/21151941
http://dx.doi.org/10.1371/journal.pone.0015154

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