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Aflatoxin B(1)-Associated DNA Adducts Stall S Phase and Stimulate Rad51 foci in Saccharomyces cerevisiae

AFB(1) is a potent recombinagen in budding yeast. AFB(1) exposure induces RAD51 expression and triggers Rad53 activation in yeast cells that express human CYP1A2. It was unknown, however, when and if Rad51 foci appear. Herein, we show that Rad53 activation correlates with cell-cycle delay in yeast a...

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Detalles Bibliográficos
Autores principales:	Fasullo, Michael, Chen, Yifan, Bortcosh, William, Sun, Minzeng, Egner, Patricia A.
Formato:	Texto
Lenguaje:	English
Publicado:	SAGE-Hindawi Access to Research 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997344/ https://www.ncbi.nlm.nih.gov/pubmed/21151658 http://dx.doi.org/10.4061/2010/456487

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