Genetic Analysis of Pathways to Parkinson Disease

In this review I outline the arguments as to whether we should consider Parkinson disease one or more than one entity and discuss genetic findings from Mendelian and whole-genome association analysis in that context. I discuss what the demonstration of disease spread implies for our analysis of the...

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Detalles Bibliográficos
Autor principal: Hardy, John
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2010
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997424/
https://www.ncbi.nlm.nih.gov/pubmed/20955928
http://dx.doi.org/10.1016/j.neuron.2010.10.014
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author Hardy, John
author_facet Hardy, John
author_sort Hardy, John
collection PubMed
description In this review I outline the arguments as to whether we should consider Parkinson disease one or more than one entity and discuss genetic findings from Mendelian and whole-genome association analysis in that context. I discuss what the demonstration of disease spread implies for our analysis of the genetic and epidemiologic risk factors for disease and outline the surprising fact that we now have genetically identified on the order of half our risk for developing the disease.
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spelling pubmed-29974242011-01-24 Genetic Analysis of Pathways to Parkinson Disease Hardy, John Neuron Perspective In this review I outline the arguments as to whether we should consider Parkinson disease one or more than one entity and discuss genetic findings from Mendelian and whole-genome association analysis in that context. I discuss what the demonstration of disease spread implies for our analysis of the genetic and epidemiologic risk factors for disease and outline the surprising fact that we now have genetically identified on the order of half our risk for developing the disease. Cell Press 2010-10-21 /pmc/articles/PMC2997424/ /pubmed/20955928 http://dx.doi.org/10.1016/j.neuron.2010.10.014 Text en © 2010 ELL & Excerpta Medica. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Perspective
Hardy, John
Genetic Analysis of Pathways to Parkinson Disease
title Genetic Analysis of Pathways to Parkinson Disease
title_full Genetic Analysis of Pathways to Parkinson Disease
title_fullStr Genetic Analysis of Pathways to Parkinson Disease
title_full_unstemmed Genetic Analysis of Pathways to Parkinson Disease
title_short Genetic Analysis of Pathways to Parkinson Disease
title_sort genetic analysis of pathways to parkinson disease
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997424/
https://www.ncbi.nlm.nih.gov/pubmed/20955928
http://dx.doi.org/10.1016/j.neuron.2010.10.014
work_keys_str_mv AT hardyjohn geneticanalysisofpathwaystoparkinsondisease

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