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Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats

A total of 56 male Sprague dawley rats of uniform weight and age were randomly divided into seven groups consisting of eight rats in each group. Groups 1, 2, and 3 served as plain control, dyslipidaemic control (DL), and atorvastatin control, respectively. Groups 4, 5, 6, and 7 received 1, 0.5, 0.25...

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Autores principales: Reddy, G. Dilip, Reddy, A. Gopala, Rao, G. Srinivasa, Haritha, C., Jyothi, K.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997463/
https://www.ncbi.nlm.nih.gov/pubmed/21170253
http://dx.doi.org/10.4103/0971-6580.72678
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author Reddy, G. Dilip
Reddy, A. Gopala
Rao, G. Srinivasa
Haritha, C.
Jyothi, K.
author_facet Reddy, G. Dilip
Reddy, A. Gopala
Rao, G. Srinivasa
Haritha, C.
Jyothi, K.
author_sort Reddy, G. Dilip
collection PubMed
description A total of 56 male Sprague dawley rats of uniform weight and age were randomly divided into seven groups consisting of eight rats in each group. Groups 1, 2, and 3 served as plain control, dyslipidaemic control (DL), and atorvastatin control, respectively. Groups 4, 5, 6, and 7 received 1, 0.5, 0.25, and 0.75% fresh garlic w/w in feed, respectively in addition to the high-fat and high-cholesterol diet and administered with atorvastatin orally for 12 weeks at the rate of 10, 5, 7.5, and 2.5 mg/kg b.wt., respectively. Plasma creatinine was estimated at 4-week intervals, whereas histopathology, electron microscopy, and estimation of TBARS concentration in kidney were conducted at the end of experiment. The TBARS concentration in DL was significantly (P<0.05) increased when compared with groups 1, 3, 6, and 7. On histopathological examination, kidney sections of group 3 had mild degenerative changes in the tubules with fatty change in few tubules, while groups 4 and 5 exhibited mild-to-moderate degenerative and fatty changes in tubules with inter tubular hemorrhages. The electron microscopy of group 2 showed hypertrophy of Bowman’s capsule, while that of group 4 showed secretary deposits in the cytoplasm. The interaction studies on kidney indicated that high dose of atorvastatin + garlic has negative safety profile when compared with groups having low dose of statin and high dose of garlic.
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spelling pubmed-29974632010-12-17 Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats Reddy, G. Dilip Reddy, A. Gopala Rao, G. Srinivasa Haritha, C. Jyothi, K. Toxicol Int Original Article A total of 56 male Sprague dawley rats of uniform weight and age were randomly divided into seven groups consisting of eight rats in each group. Groups 1, 2, and 3 served as plain control, dyslipidaemic control (DL), and atorvastatin control, respectively. Groups 4, 5, 6, and 7 received 1, 0.5, 0.25, and 0.75% fresh garlic w/w in feed, respectively in addition to the high-fat and high-cholesterol diet and administered with atorvastatin orally for 12 weeks at the rate of 10, 5, 7.5, and 2.5 mg/kg b.wt., respectively. Plasma creatinine was estimated at 4-week intervals, whereas histopathology, electron microscopy, and estimation of TBARS concentration in kidney were conducted at the end of experiment. The TBARS concentration in DL was significantly (P<0.05) increased when compared with groups 1, 3, 6, and 7. On histopathological examination, kidney sections of group 3 had mild degenerative changes in the tubules with fatty change in few tubules, while groups 4 and 5 exhibited mild-to-moderate degenerative and fatty changes in tubules with inter tubular hemorrhages. The electron microscopy of group 2 showed hypertrophy of Bowman’s capsule, while that of group 4 showed secretary deposits in the cytoplasm. The interaction studies on kidney indicated that high dose of atorvastatin + garlic has negative safety profile when compared with groups having low dose of statin and high dose of garlic. Medknow Publications 2010 /pmc/articles/PMC2997463/ /pubmed/21170253 http://dx.doi.org/10.4103/0971-6580.72678 Text en © Toxicology International http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Reddy, G. Dilip
Reddy, A. Gopala
Rao, G. Srinivasa
Haritha, C.
Jyothi, K.
Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats
title Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats
title_full Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats
title_fullStr Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats
title_full_unstemmed Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats
title_short Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats
title_sort interaction study on garlic and atorvastatin with reference to nephrotoxicity in dyslipidaemic rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997463/
https://www.ncbi.nlm.nih.gov/pubmed/21170253
http://dx.doi.org/10.4103/0971-6580.72678
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