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Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats
A total of 56 male Sprague dawley rats of uniform weight and age were randomly divided into seven groups consisting of eight rats in each group. Groups 1, 2, and 3 served as plain control, dyslipidaemic control (DL), and atorvastatin control, respectively. Groups 4, 5, 6, and 7 received 1, 0.5, 0.25...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997463/ https://www.ncbi.nlm.nih.gov/pubmed/21170253 http://dx.doi.org/10.4103/0971-6580.72678 |
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author | Reddy, G. Dilip Reddy, A. Gopala Rao, G. Srinivasa Haritha, C. Jyothi, K. |
author_facet | Reddy, G. Dilip Reddy, A. Gopala Rao, G. Srinivasa Haritha, C. Jyothi, K. |
author_sort | Reddy, G. Dilip |
collection | PubMed |
description | A total of 56 male Sprague dawley rats of uniform weight and age were randomly divided into seven groups consisting of eight rats in each group. Groups 1, 2, and 3 served as plain control, dyslipidaemic control (DL), and atorvastatin control, respectively. Groups 4, 5, 6, and 7 received 1, 0.5, 0.25, and 0.75% fresh garlic w/w in feed, respectively in addition to the high-fat and high-cholesterol diet and administered with atorvastatin orally for 12 weeks at the rate of 10, 5, 7.5, and 2.5 mg/kg b.wt., respectively. Plasma creatinine was estimated at 4-week intervals, whereas histopathology, electron microscopy, and estimation of TBARS concentration in kidney were conducted at the end of experiment. The TBARS concentration in DL was significantly (P<0.05) increased when compared with groups 1, 3, 6, and 7. On histopathological examination, kidney sections of group 3 had mild degenerative changes in the tubules with fatty change in few tubules, while groups 4 and 5 exhibited mild-to-moderate degenerative and fatty changes in tubules with inter tubular hemorrhages. The electron microscopy of group 2 showed hypertrophy of Bowman’s capsule, while that of group 4 showed secretary deposits in the cytoplasm. The interaction studies on kidney indicated that high dose of atorvastatin + garlic has negative safety profile when compared with groups having low dose of statin and high dose of garlic. |
format | Text |
id | pubmed-2997463 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-29974632010-12-17 Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats Reddy, G. Dilip Reddy, A. Gopala Rao, G. Srinivasa Haritha, C. Jyothi, K. Toxicol Int Original Article A total of 56 male Sprague dawley rats of uniform weight and age were randomly divided into seven groups consisting of eight rats in each group. Groups 1, 2, and 3 served as plain control, dyslipidaemic control (DL), and atorvastatin control, respectively. Groups 4, 5, 6, and 7 received 1, 0.5, 0.25, and 0.75% fresh garlic w/w in feed, respectively in addition to the high-fat and high-cholesterol diet and administered with atorvastatin orally for 12 weeks at the rate of 10, 5, 7.5, and 2.5 mg/kg b.wt., respectively. Plasma creatinine was estimated at 4-week intervals, whereas histopathology, electron microscopy, and estimation of TBARS concentration in kidney were conducted at the end of experiment. The TBARS concentration in DL was significantly (P<0.05) increased when compared with groups 1, 3, 6, and 7. On histopathological examination, kidney sections of group 3 had mild degenerative changes in the tubules with fatty change in few tubules, while groups 4 and 5 exhibited mild-to-moderate degenerative and fatty changes in tubules with inter tubular hemorrhages. The electron microscopy of group 2 showed hypertrophy of Bowman’s capsule, while that of group 4 showed secretary deposits in the cytoplasm. The interaction studies on kidney indicated that high dose of atorvastatin + garlic has negative safety profile when compared with groups having low dose of statin and high dose of garlic. Medknow Publications 2010 /pmc/articles/PMC2997463/ /pubmed/21170253 http://dx.doi.org/10.4103/0971-6580.72678 Text en © Toxicology International http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Reddy, G. Dilip Reddy, A. Gopala Rao, G. Srinivasa Haritha, C. Jyothi, K. Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats |
title | Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats |
title_full | Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats |
title_fullStr | Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats |
title_full_unstemmed | Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats |
title_short | Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats |
title_sort | interaction study on garlic and atorvastatin with reference to nephrotoxicity in dyslipidaemic rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997463/ https://www.ncbi.nlm.nih.gov/pubmed/21170253 http://dx.doi.org/10.4103/0971-6580.72678 |
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