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Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac Hypertrophy

Cardiac hypertrophy occurs in association with heart diseases and ultimately results in cardiac dysfunction and heart failure. Histone deacetylases (HDACs) are post-translational modifying enzymes that can deacetylate histones and non-histone proteins. Research with HDAC inhibitors has provided evid...

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Autores principales: Kee, Hae Jin, Kook, Hyun
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997602/
https://www.ncbi.nlm.nih.gov/pubmed/21151616
http://dx.doi.org/10.1155/2011/928326
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author Kee, Hae Jin
Kook, Hyun
author_facet Kee, Hae Jin
Kook, Hyun
author_sort Kee, Hae Jin
collection PubMed
description Cardiac hypertrophy occurs in association with heart diseases and ultimately results in cardiac dysfunction and heart failure. Histone deacetylases (HDACs) are post-translational modifying enzymes that can deacetylate histones and non-histone proteins. Research with HDAC inhibitors has provided evidence that the class I HDACs are pro-hypertrophic. Among the class I HDACs, HDAC2 is activated by hypertrophic stresses in association with the induction of heat shock protein 70. Activated HDAC2 triggers hypertrophy by inhibiting the signal cascades of either Krüppel like factor 4 (KLF4) or inositol polyphosphate-5-phosphatase f (Inpp5f). Thus, modulators of HDAC2 enzymes, such as selective HDAC inhibitors, are considered to be an important target for heart diseases, especially for preventing cardiac hypertrophy. In contrast, class IIa HDACs have been shown to repress cardiac hypertrophy by inhibiting cardiac-specific transcription factors such as myocyte enhancer factor 2 (MEF2), GATA4, and NFAT in the heart. Studies of class IIa HDACs have shown that the underlying mechanism is regulated by nucleo-cytoplasm shuttling in response to a variety of stress signals. In this review, we focus on the class I and IIa HDACs that play critical roles in mediating cardiac hypertrophy and discuss the non-histone targets of HDACs in heart disease.
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spelling pubmed-29976022010-12-13 Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac Hypertrophy Kee, Hae Jin Kook, Hyun J Biomed Biotechnol Review Article Cardiac hypertrophy occurs in association with heart diseases and ultimately results in cardiac dysfunction and heart failure. Histone deacetylases (HDACs) are post-translational modifying enzymes that can deacetylate histones and non-histone proteins. Research with HDAC inhibitors has provided evidence that the class I HDACs are pro-hypertrophic. Among the class I HDACs, HDAC2 is activated by hypertrophic stresses in association with the induction of heat shock protein 70. Activated HDAC2 triggers hypertrophy by inhibiting the signal cascades of either Krüppel like factor 4 (KLF4) or inositol polyphosphate-5-phosphatase f (Inpp5f). Thus, modulators of HDAC2 enzymes, such as selective HDAC inhibitors, are considered to be an important target for heart diseases, especially for preventing cardiac hypertrophy. In contrast, class IIa HDACs have been shown to repress cardiac hypertrophy by inhibiting cardiac-specific transcription factors such as myocyte enhancer factor 2 (MEF2), GATA4, and NFAT in the heart. Studies of class IIa HDACs have shown that the underlying mechanism is regulated by nucleo-cytoplasm shuttling in response to a variety of stress signals. In this review, we focus on the class I and IIa HDACs that play critical roles in mediating cardiac hypertrophy and discuss the non-histone targets of HDACs in heart disease. Hindawi Publishing Corporation 2011 2010-11-29 /pmc/articles/PMC2997602/ /pubmed/21151616 http://dx.doi.org/10.1155/2011/928326 Text en Copyright © 2011 H. J. Kee and H. Kook. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kee, Hae Jin
Kook, Hyun
Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac Hypertrophy
title Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac Hypertrophy
title_full Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac Hypertrophy
title_fullStr Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac Hypertrophy
title_full_unstemmed Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac Hypertrophy
title_short Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac Hypertrophy
title_sort roles and targets of class i and iia histone deacetylases in cardiac hypertrophy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997602/
https://www.ncbi.nlm.nih.gov/pubmed/21151616
http://dx.doi.org/10.1155/2011/928326
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