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Jak2 is required for the initiation but not maintenance of prolactin-induced mammary cancer
The prolactin receptor (PRLR), its associated kinase Jak2, and Stat5 are essential for normal mammary gland development. Due to the upregulation of the PRLR and the local synthesis of its ligand in neoplastic cells, it has been proposed that PRL can act as a local growth factor in human breast cance...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997721/ https://www.ncbi.nlm.nih.gov/pubmed/20639901 http://dx.doi.org/10.1038/onc.2010.274 |