A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction

Erectile dysfunction (ED) affects up to 50% of men between the ages of 40 and 70. Treatment with PDE-5 inhibitors is effective in the majority of men with ED. However, PDE-5 inhibitors are not effective when levels of nitric oxide (NO), the principle mediator of erection, are low. The pharmacologic...

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Detalles Bibliográficos
Autores principales: Lasker, George F., Maley, Jason H., Kadowitz, Philip J.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997760/
https://www.ncbi.nlm.nih.gov/pubmed/21152267
http://dx.doi.org/10.1155/2010/730861
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author Lasker, George F.
Maley, Jason H.
Kadowitz, Philip J.
author_facet Lasker, George F.
Maley, Jason H.
Kadowitz, Philip J.
author_sort Lasker, George F.
collection PubMed
description Erectile dysfunction (ED) affects up to 50% of men between the ages of 40 and 70. Treatment with PDE-5 inhibitors is effective in the majority of men with ED. However, PDE-5 inhibitors are not effective when levels of nitric oxide (NO), the principle mediator of erection, are low. The pharmacologic actions of three new potential treatments for ED are discussed in this paper: (1) sGC stimulators/activators, (2) Rho-kinase inhibitors, and (3) sodium nitrite.
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spelling pubmed-29977602010-12-06 A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction Lasker, George F. Maley, Jason H. Kadowitz, Philip J. Adv Pharmacol Sci Review Article Erectile dysfunction (ED) affects up to 50% of men between the ages of 40 and 70. Treatment with PDE-5 inhibitors is effective in the majority of men with ED. However, PDE-5 inhibitors are not effective when levels of nitric oxide (NO), the principle mediator of erection, are low. The pharmacologic actions of three new potential treatments for ED are discussed in this paper: (1) sGC stimulators/activators, (2) Rho-kinase inhibitors, and (3) sodium nitrite. Hindawi Publishing Corporation 2010 2010-07-18 /pmc/articles/PMC2997760/ /pubmed/21152267 http://dx.doi.org/10.1155/2010/730861 Text en Copyright © 2010 George F. Lasker et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lasker, George F.
Maley, Jason H.
Kadowitz, Philip J.
A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction
title A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction
title_full A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction
title_fullStr A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction
title_full_unstemmed A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction
title_short A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction
title_sort review of the pathophysiology and novel treatments for erectile dysfunction
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997760/
https://www.ncbi.nlm.nih.gov/pubmed/21152267
http://dx.doi.org/10.1155/2010/730861
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