O-Glycosylation Regulates Ubiquitination and Degradation of the Anti-Inflammatory Protein A20 to Accelerate Atherosclerosis in Diabetic ApoE-Null Mice

BACKGROUND: Accelerated atherosclerosis is the leading cause of morbidity and mortality in diabetic patients. Hyperglycemia is a recognized independent risk factor for heightened atherogenesis in diabetes mellitus (DM). However, our understanding of the mechanisms underlying glucose damage to the va...

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Detalles Bibliográficos
Autores principales: Shrikhande, Gautam V., Scali, Salvatore T., da Silva, Cleide G., Damrauer, Scott M., Csizmadia, Eva, Putheti, Prabhakar, Matthey, Michaela, Arjoon, Roy, Patel, Rakesh, Siracuse, Jeffrey J., Maccariello, Elizabeth R., Andersen, Nicholas D., Monahan, Thomas, Peterson, Clayton, Essayagh, Sanah, Studer, Peter, Padilha Guedes, Renata, Kocher, Olivier, Usheva, Anny, Veves, Aristidis, Kaczmarek, Elzbieta, Ferran, Christiane
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997780/
https://www.ncbi.nlm.nih.gov/pubmed/21151899
http://dx.doi.org/10.1371/journal.pone.0014240

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