Genetic and Chemical Evaluation of Trypanosoma brucei Oleate Desaturase as a Candidate Drug Target

BACKGROUND: Trypanosomes can synthesize polyunsaturated fatty acids. Previously, we have shown that they possess stearoyl-CoA desaturase (SCD) and oleate desaturase (OD) to convert stearate (C18) into oleate (C18:1) and linoleate (C18:2), respectively. Here we examine if OD is essential to these par...

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Detalles Bibliográficos
Autores principales: Alloatti, Andrés, Gupta, Shreedhara, Gualdrón-López, Melisa, Igoillo-Esteve, Mariana, Nguewa, Paul A., Deumer, Gladys, Wallemacq, Pierre, Altabe, Silvia G., Michels, Paul A. M., Uttaro, Antonio D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997783/
https://www.ncbi.nlm.nih.gov/pubmed/21151902
http://dx.doi.org/10.1371/journal.pone.0014239

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