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Ribonucleoside Triphosphates as Substrate of Human Immunodeficiency Virus Type 1 Reverse Transcriptase in Human Macrophages

We biochemically simulated HIV-1 DNA polymerization in physiological nucleotide pools found in two HIV-1 target cell types: terminally differentiated/non-dividing macrophages and activated/dividing CD4(+) T cells. Quantitative tandem mass spectrometry shows that macrophages harbor 22–320-fold lower...

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Detalles Bibliográficos
Autores principales:	Kennedy, Edward M., Gavegnano, Christina, Nguyen, Laura, Slater, Rebecca, Lucas, Amanda, Fromentin, Emilie, Schinazi, Raymond F., Kim, Baek
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998149/ https://www.ncbi.nlm.nih.gov/pubmed/20924117 http://dx.doi.org/10.1074/jbc.M110.178582

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