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Artificial Hybrids of Influenza A Virus RNA Polymerase Reveal PA Subunit Modulates Its Thermal Sensitivity

BACKGROUND: Influenza A virus can infect a variety of different hosts and therefore has to adapt to different host temperatures for its efficient viral replication. Influenza virus codes for an RNA polymerase of 3 subunits: PB1, PB2 and PA. It is well known that the PB2 subunit is involved in temper...

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Detalles Bibliográficos
Autores principales:	Kashiwagi, Takahito, Hara, Koyu, Nakazono, Yoko, Hamada, Nobuyuki, Watanabe, Hiroshi
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998429/ https://www.ncbi.nlm.nih.gov/pubmed/21151876 http://dx.doi.org/10.1371/journal.pone.0015140

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