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Domain Swapping in Allosteric Modulation of DNA Specificity

SgrAI is a type IIF restriction endonuclease that cuts an unusually long recognition sequence and exhibits allosteric self-modulation of cleavage activity and sequence specificity. Previous studies have shown that DNA bound dimers of SgrAI oligomerize into an activated form with higher DNA cleavage...

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Detalles Bibliográficos
Autores principales:	Park, Chad K., Joshi, Hemant K., Agrawal, Alka, Ghare, M. Imran, Little, Elizabeth J., Dunten, Pete W., Bitinaite, Jurate, Horton, Nancy C.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998434/ https://www.ncbi.nlm.nih.gov/pubmed/21151881 http://dx.doi.org/10.1371/journal.pbio.1000554

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