Epstein-Barr virus infection and chronic lymphocytic leukemia: a possible progression factor?

Epstein-Barr virus is pathogenically associated with a well defined group of lymphoid and epithelial tumors in which the virus directly drives transformation of infected cells. Recent evidence however indicates that this virus may infect a subpopulation of tumor cells in patients with chronic lympho...

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Detalles Bibliográficos
Autores principales: Dolcetti, Riccardo, Carbone, Antonino
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998466/
https://www.ncbi.nlm.nih.gov/pubmed/21092169
http://dx.doi.org/10.1186/1750-9378-5-22
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author Dolcetti, Riccardo
Carbone, Antonino
author_facet Dolcetti, Riccardo
Carbone, Antonino
author_sort Dolcetti, Riccardo
collection PubMed
description Epstein-Barr virus is pathogenically associated with a well defined group of lymphoid and epithelial tumors in which the virus directly drives transformation of infected cells. Recent evidence however indicates that this virus may infect a subpopulation of tumor cells in patients with chronic lymphocytic leukemia (CLL) and EBV infection has been also associated with Richter transformation in a fraction of cases. We herein review available data suggesting a possible role of EBV as a direct or micro-environmental progression factor in a subset of CLL.
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spelling pubmed-29984662010-12-08 Epstein-Barr virus infection and chronic lymphocytic leukemia: a possible progression factor? Dolcetti, Riccardo Carbone, Antonino Infect Agent Cancer Review Epstein-Barr virus is pathogenically associated with a well defined group of lymphoid and epithelial tumors in which the virus directly drives transformation of infected cells. Recent evidence however indicates that this virus may infect a subpopulation of tumor cells in patients with chronic lymphocytic leukemia (CLL) and EBV infection has been also associated with Richter transformation in a fraction of cases. We herein review available data suggesting a possible role of EBV as a direct or micro-environmental progression factor in a subset of CLL. BioMed Central 2010-11-22 /pmc/articles/PMC2998466/ /pubmed/21092169 http://dx.doi.org/10.1186/1750-9378-5-22 Text en Copyright ©2010 Dolcetti and Carbone; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Dolcetti, Riccardo
Carbone, Antonino
Epstein-Barr virus infection and chronic lymphocytic leukemia: a possible progression factor?
title Epstein-Barr virus infection and chronic lymphocytic leukemia: a possible progression factor?
title_full Epstein-Barr virus infection and chronic lymphocytic leukemia: a possible progression factor?
title_fullStr Epstein-Barr virus infection and chronic lymphocytic leukemia: a possible progression factor?
title_full_unstemmed Epstein-Barr virus infection and chronic lymphocytic leukemia: a possible progression factor?
title_short Epstein-Barr virus infection and chronic lymphocytic leukemia: a possible progression factor?
title_sort epstein-barr virus infection and chronic lymphocytic leukemia: a possible progression factor?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998466/
https://www.ncbi.nlm.nih.gov/pubmed/21092169
http://dx.doi.org/10.1186/1750-9378-5-22
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