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The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation
BACKGROUND AND PURPOSE: The phosphatidylinositol-3-kinase (PI3K)/Akt pathway is frequently deregulated in prostate cancer and associated with neoplastic transformation, malignant progression, and enhanced resistance to classical chemotherapy and radiotherapy. Thus, it is a promising target for thera...
Autores principales: | Rudner, Justine, Ruiner, Carola-Ellen, Handrick, René, Eibl, Hans-Jörg, Belka, Claus, Jendrossek, Verena |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998511/ https://www.ncbi.nlm.nih.gov/pubmed/21080918 http://dx.doi.org/10.1186/1748-717X-5-108 |
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