Selective determinants of inositol 1,4,5-trisphosphate and adenophostin A interactions with type 1 inositol 1,4,5-trisphosphate receptors

BACKGROUND AND PURPOSE: Adenophostin A (AdA) is a potent agonist of inositol 1,4,5-trisphosphate receptors (IP(3)R). AdA shares with IP(3) the essential features of all IP(3)R agonists, namely structures equivalent to the 4,5-bisphosphate and 6-hydroxyl of IP(3), but the basis of its increased affin...

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Detalles Bibliográficos
Autores principales: Rossi, Ana M, Sureshan, Kana M, Riley, Andrew M, Potter, Barry VL, Taylor, Colin W
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998688/
https://www.ncbi.nlm.nih.gov/pubmed/20977457
http://dx.doi.org/10.1111/j.1476-5381.2010.00947.x

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