Novel insertion mutation of ABCB1 gene in an ivermectin-sensitive Border Collie

P-glycoprotein (P-gp) is encoded by the ABCB1 gene and acts as an efflux pump for xenobiotics. In the Border Collie, a nonsense mutation caused by a 4-base pair deletion in the ABCB1 gene is associated with a premature stop to P-gp synthesis. In this study, we examined the full-length coding sequenc...

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Detalles Bibliográficos
Autores principales: Han, Jae-Ik, Son, Hyoung-Won, Park, Seung-Cheol, Na, Ki-Jeong
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998746/
https://www.ncbi.nlm.nih.gov/pubmed/21113104
http://dx.doi.org/10.4142/jvs.2010.11.4.341

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