Life and destruction: ubiquitin-mediated proteolysis in aging and longevity

The ubiquitin/proteasome system (UPS) regulates the turnover of improperly folded and damaged proteins to maintain protein homeostasis (proteostasis), cellular function, and viability. It is commonly thought that an age-related impairment of the UPS affects general proteostasis networks, which cause...

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Detalles Bibliográficos
Autor principal: Hoppe, Thorsten
Formato: Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998811/
https://www.ncbi.nlm.nih.gov/pubmed/21151840
http://dx.doi.org/10.3410/B2-79
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author Hoppe, Thorsten
author_facet Hoppe, Thorsten
author_sort Hoppe, Thorsten
collection PubMed
description The ubiquitin/proteasome system (UPS) regulates the turnover of improperly folded and damaged proteins to maintain protein homeostasis (proteostasis), cellular function, and viability. It is commonly thought that an age-related impairment of the UPS affects general proteostasis networks, which causes enhanced protein aggregation and contributes to normal aging. Recent studies identified the existence of ubiquitin-dependent degradation pathways that specifically control lifespan regulators, suggesting additional roles for ubiquitylation in aging and longevity.
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spelling pubmed-29988112010-12-10 Life and destruction: ubiquitin-mediated proteolysis in aging and longevity Hoppe, Thorsten F1000 Biol Rep Review Article The ubiquitin/proteasome system (UPS) regulates the turnover of improperly folded and damaged proteins to maintain protein homeostasis (proteostasis), cellular function, and viability. It is commonly thought that an age-related impairment of the UPS affects general proteostasis networks, which causes enhanced protein aggregation and contributes to normal aging. Recent studies identified the existence of ubiquitin-dependent degradation pathways that specifically control lifespan regulators, suggesting additional roles for ubiquitylation in aging and longevity. Faculty of 1000 Ltd 2010-11-11 /pmc/articles/PMC2998811/ /pubmed/21151840 http://dx.doi.org/10.3410/B2-79 Text en © 2010 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Hoppe, Thorsten
Life and destruction: ubiquitin-mediated proteolysis in aging and longevity
title Life and destruction: ubiquitin-mediated proteolysis in aging and longevity
title_full Life and destruction: ubiquitin-mediated proteolysis in aging and longevity
title_fullStr Life and destruction: ubiquitin-mediated proteolysis in aging and longevity
title_full_unstemmed Life and destruction: ubiquitin-mediated proteolysis in aging and longevity
title_short Life and destruction: ubiquitin-mediated proteolysis in aging and longevity
title_sort life and destruction: ubiquitin-mediated proteolysis in aging and longevity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998811/
https://www.ncbi.nlm.nih.gov/pubmed/21151840
http://dx.doi.org/10.3410/B2-79
work_keys_str_mv AT hoppethorsten lifeanddestructionubiquitinmediatedproteolysisinagingandlongevity

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