The role of microRNAs in acute myeloid leukemia

MicroRNAs (miRs) are short (18-22 nucleotides) non-coding RNAs that are important in regulating gene expression. MiR expression is deregulated in many types of cancers, including leukemias. In acute myeloid leukemia (AML), the expression of specific miRs has been linked with both prognostically and...

Descripción completa

Detalles Bibliográficos
Autores principales: Hyde, R Katherine, Liu, P Paul
Formato: Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998852/
https://www.ncbi.nlm.nih.gov/pubmed/21170374
http://dx.doi.org/10.3410/B2-81
_version_ 1782193406221484032
author Hyde, R Katherine
Liu, P Paul
author_facet Hyde, R Katherine
Liu, P Paul
author_sort Hyde, R Katherine
collection PubMed
description MicroRNAs (miRs) are short (18-22 nucleotides) non-coding RNAs that are important in regulating gene expression. MiR expression is deregulated in many types of cancers, including leukemias. In acute myeloid leukemia (AML), the expression of specific miRs has been linked with both prognostically and cytogenetically defined subgroups. Recent studies have shown that deregulation of miR expression is not simply a consequence of AML but a potential contributer to leukemogenesis. This commentary will focus on select findings that describe the different mechanistic roles for miRs in the development of leukemia.
format Text
id pubmed-2998852
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Faculty of 1000 Ltd
record_format MEDLINE/PubMed
spelling pubmed-29988522010-12-17 The role of microRNAs in acute myeloid leukemia Hyde, R Katherine Liu, P Paul F1000 Biol Rep Review Article MicroRNAs (miRs) are short (18-22 nucleotides) non-coding RNAs that are important in regulating gene expression. MiR expression is deregulated in many types of cancers, including leukemias. In acute myeloid leukemia (AML), the expression of specific miRs has been linked with both prognostically and cytogenetically defined subgroups. Recent studies have shown that deregulation of miR expression is not simply a consequence of AML but a potential contributer to leukemogenesis. This commentary will focus on select findings that describe the different mechanistic roles for miRs in the development of leukemia. Faculty of 1000 Ltd 2010-11-24 /pmc/articles/PMC2998852/ /pubmed/21170374 http://dx.doi.org/10.3410/B2-81 Text en © 2010 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Hyde, R Katherine
Liu, P Paul
The role of microRNAs in acute myeloid leukemia
title The role of microRNAs in acute myeloid leukemia
title_full The role of microRNAs in acute myeloid leukemia
title_fullStr The role of microRNAs in acute myeloid leukemia
title_full_unstemmed The role of microRNAs in acute myeloid leukemia
title_short The role of microRNAs in acute myeloid leukemia
title_sort role of micrornas in acute myeloid leukemia
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998852/
https://www.ncbi.nlm.nih.gov/pubmed/21170374
http://dx.doi.org/10.3410/B2-81
work_keys_str_mv AT hyderkatherine theroleofmicrornasinacutemyeloidleukemia
AT liuppaul theroleofmicrornasinacutemyeloidleukemia
AT hyderkatherine roleofmicrornasinacutemyeloidleukemia
AT liuppaul roleofmicrornasinacutemyeloidleukemia

Ejemplares similares