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Hepatitis C Virus Core Protein Abrogates the DDX3 Function That Enhances IPS-1-Mediated IFN–Beta Induction

The DEAD box helicase DDX3 assembles IPS-1 (also called Cardif, MAVS, or VISA) in non-infected human cells where minimal amounts of the RIG-I-like receptor (RLR) protein are expressed. DDX3 C-terminal regions directly bind the IPS-1 CARD-like domain as well as the N-terminal hepatitis C virus (HCV)...

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Detalles Bibliográficos
Autores principales:	Oshiumi, Hiroyuki, Ikeda, Masanori, Matsumoto, Misako, Watanabe, Ayako, Takeuchi, Osamu, Akira, Shizuo, Kato, Nobuyuki, Shimotohno, Kunitada, Seya, Tsukasa
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999533/ https://www.ncbi.nlm.nih.gov/pubmed/21170385 http://dx.doi.org/10.1371/journal.pone.0014258

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