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Parallel processing of visual space by neighboring neurons in mouse visual cortex

Visual cortex exhibits smooth retinotopic organization on the macroscopic scale, but it is unknown how receptive fields are organized at the level of neighboring neurons. This information is crucial for discriminating among models of visual cortex. We used in vivo two-photon calcium imaging to indep...

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Detalles Bibliográficos
Autores principales: Smith, Spencer L., Häusser, Michael
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999824/
https://www.ncbi.nlm.nih.gov/pubmed/20711183
http://dx.doi.org/10.1038/nn.2620
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author Smith, Spencer L.
Häusser, Michael
author_facet Smith, Spencer L.
Häusser, Michael
author_sort Smith, Spencer L.
collection PubMed
description Visual cortex exhibits smooth retinotopic organization on the macroscopic scale, but it is unknown how receptive fields are organized at the level of neighboring neurons. This information is crucial for discriminating among models of visual cortex. We used in vivo two-photon calcium imaging to independently map ON and OFF receptive field subregions of local populations of layer 2/3 neurons in mouse visual cortex. We found that receptive field subregions are often precisely shared among multiple neighboring neurons. Furthermore, large subregions appear to be assembled from multiple smaller, non-overlapping subregions of other neurons in the same local population. These experiments provide the first characterization of the diversity of receptive fields in a dense local network of visual cortex, and reveal elementary units of receptive field organization. Our results suggest that a limited pool of afferent receptive fields is available to a local population of neurons, and reveal new organizational principles for the neural circuitry of the mouse visual cortex.
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spelling pubmed-29998242011-03-01 Parallel processing of visual space by neighboring neurons in mouse visual cortex Smith, Spencer L. Häusser, Michael Nat Neurosci Article Visual cortex exhibits smooth retinotopic organization on the macroscopic scale, but it is unknown how receptive fields are organized at the level of neighboring neurons. This information is crucial for discriminating among models of visual cortex. We used in vivo two-photon calcium imaging to independently map ON and OFF receptive field subregions of local populations of layer 2/3 neurons in mouse visual cortex. We found that receptive field subregions are often precisely shared among multiple neighboring neurons. Furthermore, large subregions appear to be assembled from multiple smaller, non-overlapping subregions of other neurons in the same local population. These experiments provide the first characterization of the diversity of receptive fields in a dense local network of visual cortex, and reveal elementary units of receptive field organization. Our results suggest that a limited pool of afferent receptive fields is available to a local population of neurons, and reveal new organizational principles for the neural circuitry of the mouse visual cortex. 2010-08-15 2010-09 /pmc/articles/PMC2999824/ /pubmed/20711183 http://dx.doi.org/10.1038/nn.2620 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Smith, Spencer L.
Häusser, Michael
Parallel processing of visual space by neighboring neurons in mouse visual cortex
title Parallel processing of visual space by neighboring neurons in mouse visual cortex
title_full Parallel processing of visual space by neighboring neurons in mouse visual cortex
title_fullStr Parallel processing of visual space by neighboring neurons in mouse visual cortex
title_full_unstemmed Parallel processing of visual space by neighboring neurons in mouse visual cortex
title_short Parallel processing of visual space by neighboring neurons in mouse visual cortex
title_sort parallel processing of visual space by neighboring neurons in mouse visual cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999824/
https://www.ncbi.nlm.nih.gov/pubmed/20711183
http://dx.doi.org/10.1038/nn.2620
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