Calcium and Neurogenesis in Alzheimer's Disease

It was evidenced that impairment of calcium homeostasis is a potential mechanism in the development of Alzheimer's disease (AD). It remains, however, unclear how the calcium signaling are associated with in AD progression. Here we review recent studies to discuss the relationship among the sign...

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Detalles Bibliográficos
Autores principales: Wang, Jun Ming, Sun, Chenyou
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2010
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999846/
https://www.ncbi.nlm.nih.gov/pubmed/21151820
http://dx.doi.org/10.3389/fnins.2010.00194
Descripción
Sumario:It was evidenced that impairment of calcium homeostasis is a potential mechanism in the development of Alzheimer's disease (AD). It remains, however, unclear how the calcium signaling are associated with in AD progression. Here we review recent studies to discuss the relationship among the signaling of intracellular calcium concentration, neurogenic activity, and AD progression. Analyzing these findings may provide new ideas to improve the neurogenic status in pathological processes in the aging brain.

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