Role of clusters in insulin-regulated GLUT4 trafficking in adipose cells: A new paradigm?

Insulin stimulates glucose transport in muscle and adipose cells by stimulating translocation of glucose transporter 4 (GLUT4) to the plasma membrane. In a recent Cell Metabolism paper, Stenkula et al. found that insulin controls the spatial distribution of GLUT4 on the surface of isolated adipose c...

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Detalles Bibliográficos
Autor principal: Yang, Jian
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2010
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999848/
https://www.ncbi.nlm.nih.gov/pubmed/21152264
Descripción
Sumario:Insulin stimulates glucose transport in muscle and adipose cells by stimulating translocation of glucose transporter 4 (GLUT4) to the plasma membrane. In a recent Cell Metabolism paper, Stenkula et al. found that insulin controls the spatial distribution of GLUT4 on the surface of isolated adipose cells through regulation of their post-fusion dispersal. The presence of GLUT4 in plasma membrane-associated clusters is suggestive of a new paradigm in membrane protein recycling.

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