Role of clusters in insulin-regulated GLUT4 trafficking in adipose cells: A new paradigm?

Insulin stimulates glucose transport in muscle and adipose cells by stimulating translocation of glucose transporter 4 (GLUT4) to the plasma membrane. In a recent Cell Metabolism paper, Stenkula et al. found that insulin controls the spatial distribution of GLUT4 on the surface of isolated adipose c...

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Detalles Bibliográficos
Autor principal: Yang, Jian
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2010
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999848/
https://www.ncbi.nlm.nih.gov/pubmed/21152264
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author Yang, Jian
author_facet Yang, Jian
author_sort Yang, Jian
collection PubMed
description Insulin stimulates glucose transport in muscle and adipose cells by stimulating translocation of glucose transporter 4 (GLUT4) to the plasma membrane. In a recent Cell Metabolism paper, Stenkula et al. found that insulin controls the spatial distribution of GLUT4 on the surface of isolated adipose cells through regulation of their post-fusion dispersal. The presence of GLUT4 in plasma membrane-associated clusters is suggestive of a new paradigm in membrane protein recycling.
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spelling pubmed-29998482010-12-09 Role of clusters in insulin-regulated GLUT4 trafficking in adipose cells: A new paradigm? Yang, Jian Int J Biol Sci Commentary Insulin stimulates glucose transport in muscle and adipose cells by stimulating translocation of glucose transporter 4 (GLUT4) to the plasma membrane. In a recent Cell Metabolism paper, Stenkula et al. found that insulin controls the spatial distribution of GLUT4 on the surface of isolated adipose cells through regulation of their post-fusion dispersal. The presence of GLUT4 in plasma membrane-associated clusters is suggestive of a new paradigm in membrane protein recycling. Ivyspring International Publisher 2010-11-25 /pmc/articles/PMC2999848/ /pubmed/21152264 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Commentary
Yang, Jian
Role of clusters in insulin-regulated GLUT4 trafficking in adipose cells: A new paradigm?
title Role of clusters in insulin-regulated GLUT4 trafficking in adipose cells: A new paradigm?
title_full Role of clusters in insulin-regulated GLUT4 trafficking in adipose cells: A new paradigm?
title_fullStr Role of clusters in insulin-regulated GLUT4 trafficking in adipose cells: A new paradigm?
title_full_unstemmed Role of clusters in insulin-regulated GLUT4 trafficking in adipose cells: A new paradigm?
title_short Role of clusters in insulin-regulated GLUT4 trafficking in adipose cells: A new paradigm?
title_sort role of clusters in insulin-regulated glut4 trafficking in adipose cells: a new paradigm?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999848/
https://www.ncbi.nlm.nih.gov/pubmed/21152264
work_keys_str_mv AT yangjian roleofclustersininsulinregulatedglut4traffickinginadiposecellsanewparadigm

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