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Viral Oncogenes, Noncoding RNAs, and RNA Splicing in Human Tumor Viruses
Viral oncogenes are responsible for oncogenesis resulting from persistent virus infection. Although different human tumor viruses express different viral oncogenes and induce different tumors, their oncoproteins often target similar sets of cellular tumor suppressors or signal pathways to immortaliz...
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Formato: | Texto |
Lenguaje: | English |
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Ivyspring International Publisher
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999850/ https://www.ncbi.nlm.nih.gov/pubmed/21152115 |
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author | Zheng, Zhi-Ming |
author_facet | Zheng, Zhi-Ming |
author_sort | Zheng, Zhi-Ming |
collection | PubMed |
description | Viral oncogenes are responsible for oncogenesis resulting from persistent virus infection. Although different human tumor viruses express different viral oncogenes and induce different tumors, their oncoproteins often target similar sets of cellular tumor suppressors or signal pathways to immortalize and/or transform infected cells. Expression of the viral E6 and E7 oncogenes in papillomavirus, E1A and E1B oncogenes in adenovirus, large T and small t antigen in polyomavirus, and Tax oncogene in HTLV-1 are regulated by alternative RNA splicing. However, this regulation is only partially understood. DNA tumor viruses also encode noncoding RNAs, including viral microRNAs, that disturb normal cell functions. Among the determined viral microRNA precursors, EBV encodes 25 from two major clusters (BART and BHRF1), KSHV encodes 12 from a latent region, human polyomavirus MCV produce only one microRNA from the late region antisense to early transcripts, but HPVs appears to produce no viral microRNAs. |
format | Text |
id | pubmed-2999850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-29998502010-12-09 Viral Oncogenes, Noncoding RNAs, and RNA Splicing in Human Tumor Viruses Zheng, Zhi-Ming Int J Biol Sci Review Viral oncogenes are responsible for oncogenesis resulting from persistent virus infection. Although different human tumor viruses express different viral oncogenes and induce different tumors, their oncoproteins often target similar sets of cellular tumor suppressors or signal pathways to immortalize and/or transform infected cells. Expression of the viral E6 and E7 oncogenes in papillomavirus, E1A and E1B oncogenes in adenovirus, large T and small t antigen in polyomavirus, and Tax oncogene in HTLV-1 are regulated by alternative RNA splicing. However, this regulation is only partially understood. DNA tumor viruses also encode noncoding RNAs, including viral microRNAs, that disturb normal cell functions. Among the determined viral microRNA precursors, EBV encodes 25 from two major clusters (BART and BHRF1), KSHV encodes 12 from a latent region, human polyomavirus MCV produce only one microRNA from the late region antisense to early transcripts, but HPVs appears to produce no viral microRNAs. Ivyspring International Publisher 2010-12-01 /pmc/articles/PMC2999850/ /pubmed/21152115 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. |
spellingShingle | Review Zheng, Zhi-Ming Viral Oncogenes, Noncoding RNAs, and RNA Splicing in Human Tumor Viruses |
title | Viral Oncogenes, Noncoding RNAs, and RNA Splicing in Human Tumor Viruses |
title_full | Viral Oncogenes, Noncoding RNAs, and RNA Splicing in Human Tumor Viruses |
title_fullStr | Viral Oncogenes, Noncoding RNAs, and RNA Splicing in Human Tumor Viruses |
title_full_unstemmed | Viral Oncogenes, Noncoding RNAs, and RNA Splicing in Human Tumor Viruses |
title_short | Viral Oncogenes, Noncoding RNAs, and RNA Splicing in Human Tumor Viruses |
title_sort | viral oncogenes, noncoding rnas, and rna splicing in human tumor viruses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999850/ https://www.ncbi.nlm.nih.gov/pubmed/21152115 |
work_keys_str_mv | AT zhengzhiming viraloncogenesnoncodingrnasandrnasplicinginhumantumorviruses |