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Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs
Early diagnosis of cancer is of pivotal importance to reduce disease-related mortality. There is great need for non-invasive screening methods, yet current screening protocols have limited sensitivity and specificity. The use of serum biomarkers to discriminate cancer patients from healthy persons m...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000077/ https://www.ncbi.nlm.nih.gov/pubmed/21151433 http://dx.doi.org/10.3390/ijms11114175 |
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author | Huijbers, Anouck Velstra, Berit Dekker, Tim J. A. Mesker, Wilma E. van der Burgt, Yuri E. M. Mertens, Bart J. Deelder, André M. Tollenaar, Rob A. E. M. |
author_facet | Huijbers, Anouck Velstra, Berit Dekker, Tim J. A. Mesker, Wilma E. van der Burgt, Yuri E. M. Mertens, Bart J. Deelder, André M. Tollenaar, Rob A. E. M. |
author_sort | Huijbers, Anouck |
collection | PubMed |
description | Early diagnosis of cancer is of pivotal importance to reduce disease-related mortality. There is great need for non-invasive screening methods, yet current screening protocols have limited sensitivity and specificity. The use of serum biomarkers to discriminate cancer patients from healthy persons might be a tool to improve screening programs. Mass spectrometry based proteomics is widely applied as a technology for mapping and identifying peptides and proteins in body fluids. One commonly used approach in proteomics is peptide and protein profiling. Here, we present an overview of profiling methods that have the potential for implementation in a clinical setting and in national screening programs. |
format | Text |
id | pubmed-3000077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-30000772010-12-10 Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs Huijbers, Anouck Velstra, Berit Dekker, Tim J. A. Mesker, Wilma E. van der Burgt, Yuri E. M. Mertens, Bart J. Deelder, André M. Tollenaar, Rob A. E. M. Int J Mol Sci Review Early diagnosis of cancer is of pivotal importance to reduce disease-related mortality. There is great need for non-invasive screening methods, yet current screening protocols have limited sensitivity and specificity. The use of serum biomarkers to discriminate cancer patients from healthy persons might be a tool to improve screening programs. Mass spectrometry based proteomics is widely applied as a technology for mapping and identifying peptides and proteins in body fluids. One commonly used approach in proteomics is peptide and protein profiling. Here, we present an overview of profiling methods that have the potential for implementation in a clinical setting and in national screening programs. Molecular Diversity Preservation International (MDPI) 2010-10-26 /pmc/articles/PMC3000077/ /pubmed/21151433 http://dx.doi.org/10.3390/ijms11114175 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Huijbers, Anouck Velstra, Berit Dekker, Tim J. A. Mesker, Wilma E. van der Burgt, Yuri E. M. Mertens, Bart J. Deelder, André M. Tollenaar, Rob A. E. M. Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs |
title | Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs |
title_full | Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs |
title_fullStr | Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs |
title_full_unstemmed | Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs |
title_short | Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs |
title_sort | proteomic serum biomarkers and their potential application in cancer screening programs |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000077/ https://www.ncbi.nlm.nih.gov/pubmed/21151433 http://dx.doi.org/10.3390/ijms11114175 |
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