Histone Deacetylases Suppress CGG Repeat–Induced Neurodegeneration Via Transcriptional Silencing in Models of Fragile X Tremor Ataxia Syndrome

Fragile X Tremor Ataxia Syndrome (FXTAS) is a common inherited neurodegenerative disorder caused by expansion of a CGG trinucleotide repeat in the 5′UTR of the fragile X syndrome (FXS) gene, FMR1. The expanded CGG repeat is thought to induce toxicity as RNA, and in FXTAS patients mRNA levels for FMR...

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Detalles Bibliográficos
Autores principales: Todd, Peter K., Oh, Seok Yoon, Krans, Amy, Pandey, Udai B., Di Prospero, Nicholas A., Min, Kyung-Tai, Taylor, J. Paul, Paulson, Henry L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000359/
https://www.ncbi.nlm.nih.gov/pubmed/21170301
http://dx.doi.org/10.1371/journal.pgen.1001240

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